ArticleMagnetic resonance in medicine2025
Improving quantitative BOLD-based measures of oxygen extraction fraction using hyperoxia BOLD-derived measures of blood volume.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recent advances in MR neuroimaging: toward quantitative and AI-driven brain and spinal cord imaging.Japanese journal of radiology · 2026Review
- Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.Science advances · 2026Article
- Heterogeneity, Measurement, and Clinical Implications of Oxygenation, Cell Signaling, and Redox Biology in Glioblastoma and Adult Diffuse Gliomas, with Context from Other Brain Tumors.Antioxidants (Basel, Switzerland) · 2026Review
- Improving quantitative BOLD-based measures of oxygen extraction fraction using hyperoxia BOLD-derived measures of blood volume.Magnetic resonance in medicine · 2025Article
- Article
- Cerebral oxygen metabolism from MRI susceptibility.NeuroImage · 2023Review
- Cerebral oxygen extraction fraction MRI: Techniques and applications.Magnetic resonance in medicine · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purposeStreamlined quantitative BOLD (sqBOLD) is a refinement of the quantitative BOLD (qBOLD) technique capable of producing noninvasive and quantitative maps of oxygen extraction fraction (OEF) in a clinically feasible scan time. However, sqBOLD measurements of OEF have been reported as being systematically lower than expected in healthy brain. Because the qBOLD framework infers OEF from the ratio of the reversible transverse relaxation rate (
methodsMonte Carlo simulations were used to simulate the qBOLD and hyperoxia-BOLD signals and to compare the systematic and noise-related errors of sqBOLD and the new hyperoxia-qBOLD (hqBOLD) technique. Experimentally, sqBOLD and hqBOLD measurements were performed and compared with TRUST (T
resultsSimulations showed a large improvement in the uncertainty of DBV measurements, leading to a much improved dynamic range for OEF measurements with hqBOLD. In a group of 10 healthy volunteers, hqBOLD produced measurements of OEF in cortical gray matter (OEF
conclusionThe simulations and experiments in this study demonstrate that an independent measure of DBV provides improved estimates of OEF.
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