Evidence map›Paper›PMID 40391640›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Hydrogel-Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases.

Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kenny Zhuoran WuDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.ORCID https://orcid.org/0000-0003-1733-7622
Rockie Haiyao DingDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.
Zixuan ZhaoThe N.1 Institute for Health, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore.
Clara Yieh Lin ChongLaboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Center Singapore, 30 Hospital Boulevard, Singapore, 168583, Singapore.
Ruochii YouDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.
Hengjia ZhouDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.
Dong Hua SeahDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.
Wei Qiang LeowDepartment of Anatomical Pathology, Division of Pathology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.
Hong Kit LimSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Sukanya ShyamasundarMultiphoton Microscopy Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Singapore.
Kanishka FernandoDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.
Fathima Farzana KuthubudeenDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.
Gillian NgLaboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Center Singapore, 30 Hospital Boulevard, Singapore, 168583, Singapore.
Chor Yong TaySchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Narayanan Gopalakrishna IyerDivision of Surgical Oncology, National Cancer Center Singapore, 30 Hospital Boulevard, Singapore, 168583, Singapore.
Chin-Ann Johnny OngLaboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Center Singapore, 30 Hospital Boulevard, Singapore, 168583, Singapore.
Eliza Li Shan FongDepartment of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore, 119276, Singapore.ORCID https://orcid.org/0000-0001-5770-0700

Funding

Clinician Scientist Award MOH-001288Ministry of Education - Singapore T2EP30221-0016National Cancer Centre of SingaporeNational Medical Research Council MOH-001573National Medical Research Council Clinician Scientist-Individual Research Grant MOH-000969National Medical Research Council Clinician Scientist-Individual Research Grant MOH-001590NCCS Cancer FundNMRC Individual Research Grant MOH-001212-01
6 · The paper itself

Abstract

Clinically effective treatments for peritoneal metastases (PM) remain a significant unmet need. To expedite drug development in PM, hyaluronan (HA) hydrogel-supported PM patient-derived tumor explants (PDTE) that better preserve histological features, composition, and biological pathways of the original tumor, as compared to conventional PDTE culture methods are developed. Hydrogel modulation shows that stiffness, degradation, three-dimensional embedding, and HA itself are key parameters that enhance PDTE maintenance ex vivo. Further, HA hydrogels effectively preserve PDTE viability by disrupting myosin II-mediated tissue contraction, a phenomenon that occurs in the absence of hydrogel embedding. Lastly, the addition of ascites into PM PDTE not only recapitulates changes to the tumor microenvironment as observed in patients but also ascites-dependent drug efficacy, highlighting the importance of incorporating ascites into ex vivo PM models for accurate therapeutic evaluation. The bioengineered PM PDTE models in this study serve as a valuable platform for drug development and treatment personalization.

Indexed as

Antineoplastic AgentsHydrogelsPeritoneal NeoplasmsAnimalsAscitesCell Line, TumorCell SurvivalHumansHyaluronic AcidTumor MicroenvironmentAntineoplastic AgentsHyaluronic AcidHydrogelsdrug developmenthyaluronan hydrogelspatient‐derived tumor explantsperitoneal metastasespersonalized oncology

Identifiers

PMID40391640
PMCPMC12369685

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.