ArticleNanomedicine (London, England)2025
Article in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Mechanisms and Translational Potential of Plant-Derived Extracellular Vesicles in Cardiovascular Disease.Cells · 2026Review
- Plant-derived extracellular vesicles as emerging cardioprotective agents for cardiovascular diseases.Journal of nanobiotechnology · 2026Review
- Plant-Derived Nanovesicles: A Comprehensive Review from Isolation to Clinical Translation-Unlocking Natural Nanocarriers for Biomedical Applications.Biomolecules · 2026Review
- Extracellular vesicles at the immune-metabolic crossroads of Hashimoto's thyroiditis and diabetes mellitus.Frontiers in immunology · 2026Review
- Advances in the application of nanoparticles for the diagnosis and treatment of diabetic cardiomyopathy.Frontiers in cell and developmental biology · 2026Review
- The regulatory mechanism of NLRP3 inflammasome in the "immune paralytic-overactivation" imbalance in sepsis: the latest progress from molecular signaling to clinical translation.Frontiers in immunology · 2026Review
- Mechanisms and emerging research trends of angiogenesis promotion by small extracellular vesicles from different cellular sources in alleviating myocardial infarction injury.Frontiers in pharmacology · 2026Review
- Plant-Derived Extracellular-Vesicle-Like Particles: Immune Regulation and Disease Therapy.Research (Washington, D.C.) · 2026Review
- Advances in understanding exosome-mediated regulation of macrophage function.Frontiers in immunology · 2026Review
- Bioengineering Applications of Chinese Herbal Medicine-Derived Exosomes in Cardiovascular Diseases: Mechanisms and Translational Prospects.Drug design, development and therapy · 2026Review
- Regulated Cell Death and Inflammatory Signaling in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Strategies.Journal of cardiovascular translational research · 2025Review
- Ubiquitination-mediated protein homeostasis in cardiovascular diseases: molecular mechanisms and therapeutic opportunities.American journal of cardiovascular disease · 2025Review
- Isolation of exosome-like nanovesicles from Yiqi Huoxue Jiedu decoction and their anti-ovarian cancer activity.Frontiers in pharmacology · 2025Article
- Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimExosome-like nanoparticles mediate intercellular communication and regulate gene expression. In this study, we isolated and purified exosome-like nanoparticles from MATERIALS &
methodsTo investigate the effect of SM-ELNs on DCM, we established a mouse model via HFD/STZ treatment. Cardiac function was assessed by echocardiography. Cardiac hypertrophy was assessed by measuring the heart weight/body weight ratio and HE staining, while myocardial fibrosis was evaluated using Masson's trichrome staining. The role of SM-ELNs on NLRP3 inflammasome inhibition and macrophage pyroptosis were evaluated both in vivo and in vitro. The interaction between NEDD4 and SGK1 was analyzed by Co-IP and ubiquitination assays.
resultsSM-ELNs treatment alleviated cardiac function and histopathological changes in DCM mice. Moreover, SM-ELNs suppressed NLRP3 inflammasome activation and subsequent macrophage pyroptosis in both in vivo and in vitro models. Mechanistically, NEDD4 facilitated the ubiquitination and degradation of SGK1 in macrophages. Both NEDD4 depletion and SGK1 addition could counteract the SM-ELNs-induced suppression of NLRP3 inflammasome-triggered macrophage pyroptosis in LPS/ATP-treated RAW264.7 cells.
conclusionOur study provides the first evidence that SM-ELNs inhibit NLRP3 inflammasome-mediated macrophage pyroptosis in DCM by modulating the NEDD4/SGK1 axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.