Evidence map›Paper›PMID 40391390›Full record

ArticleAmerican heart journal plus : cardiology research and practice2025

Refractory angina in women with ischemia and no obstructive coronary artery disease - A report from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study.

Judy M Luu, Janet Wei, Chrisandra Shufelt, Anum Asif, Benita Tjoe, Galen Cook-Wiens, Eileen M Handberg, Puja K Mehta, Jenna Maughan, Daniel S Berman and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00832702 (Women's Ischemia Syndrome Evaluation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00832702 active not recruitingnot on this map

Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction

TypeobservationalSponsorCedars-Sinai Medical CenterRan2008 to 2051Enrolled433ConditionsCardiovascular DiseaseArmsCardiac MRI
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Judy M LuuDivision of Cardiology, McGill University Health Center, Montreal, Quebec, Canada.
Janet WeiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Chrisandra ShufeltBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Anum AsifBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Benita TjoeBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Galen Cook-WiensBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Eileen M HandbergDivision of Cardiology, University of Florida, Gainesville, FL, USA.
Puja K MehtaDepartment of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
Jenna MaughanBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel S BermanS. Mark Taper Foundation Imaging Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Louise E J ThomsonS. Mark Taper Foundation Imaging Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Carl J PepineDivision of Cardiology, University of Florida, Gainesville, FL, USA.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Women with suspected ischemia and no obstructive coronary artery disease (INOCA) are often challenging to manage. We aimed to understand mechanisms and treatable pathways of refractory angina. Methods: The Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction (NCT00832702) recruited women between 2008 and 2015. In a pre-defined subgroup ( Results: Women with refractory angina ( Conclusions: Refractory angina is common in women with INOCA. Hypertension and endothelial-dependent microvascular dysfunction are independently associated with a 4- and 3-fold increase in refractory angina at 1-year, respectively. These findings may identify potential treatment targets to reduce angina burden in INOCA.

Indexed as

CMRIINOCARefractory anginaSAQ

Identifiers

PMID40391390
PMCPMC12088774

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.