ArticlePlastic and reconstructive surgery. Global open2025
Defining Breast Implant Illness: A Systematic Review and Meta-analysis of Patient-reported Symptoms.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Breast Reconstruction After Cancer: Historical Development, Modern Techniques, and Psychological Impact.Healthcare (Basel, Switzerland) · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although no definitive scientific link has been established, public concern surrounding breast implant illness (BII) is increasing. To study this potential condition, a clear definition is necessary. This systematic review aimed to characterize BII through a meta-analysis of patient-reported symptoms. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a comprehensive literature search was conducted. The relative risk (RR) of the top 10 symptoms was meta-analyzed, comparing patients with and without breast implants. Additional analyses assessed whether surgical or patient-related factors influenced symptom occurrence. Results: A total of 36 articles were included in this study, accounting for 10,519 patients. Fatigue or malaise (RR = 3.15 [2.89-3.43]), myalgia or weakness (RR = 2.96 [2.76-3.18]), and cognitive dysfunction (RR = 2.87 [2.64-3.12]) were most strongly associated with the presence of breast implants. Implants that were ruptured (RR = 1.12 [1.04-1.21], Conclusions: Given increasing awareness and concern surrounding BII, it is essential for the plastic surgery community to critically examine patient outcomes. Establishing a consistent, symptom-based definition of BII and identifying key risk factors are necessary to guide future research and improve patient care.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.