Evidence map›Paper›PMID 40391325›Full record

ArticlebioRxiv : the preprint server for biology2025

p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration.

Ravi Kumar, Simon Couly, Bruna R Muys, Xiao Ling Li, Ioannis Grammatikakis, Ragini Singh, Mary Guest, Xinyu Wen, Wei Tang, Stefan Ambs and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ravi KumarRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Simon CoulyCellular Pathobiology Section, Integrative Neuroscience Branch, National Institute on Drug Abuse (NIDA), NIH, Baltimore, MD, USA.
Bruna R MuysRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Xiao Ling LiRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Ioannis GrammatikakisRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-8455-1584
Ragini SinghRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Mary GuestGenome Modification Core, Frederick National Lab for Cancer Research, NCI, NIH, Frederick, MD, USA.
Xinyu WenOncogenomics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Wei TangLaboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD, USA.
Stefan AmbsLaboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD, USA.
Lisa M JenkinsMass Spectrometry Section, Laboratory of Cell Biology, CCR, NCI, NIH, Bethesda, MD, USA.ORCID 0000-0003-1245-1338
Erica C PehrssonAdvanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Raj ChariGenome Modification Core, Frederick National Lab for Cancer Research, NCI, NIH, Frederick, MD, USA.
Tsung-Ping SuCellular Pathobiology Section, Integrative Neuroscience Branch, National Institute on Drug Abuse (NIDA), NIH, Baltimore, MD, USA.
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-4299-8177

Funding

Role of long non-coding RNAs in p53 signalingZIABC011646 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAL, ASHISH · 2015 to 2025
$15.0M
Intramural NIH HHS ZIA BC011646
6 · The paper itself

Abstract

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing regulator that functions in p53-dependent tumor suppression

Indexed as

cancerhexokinaseHKDC1JUNmitochondrial respirationp53proliferationproteomicsRNA-binding proteintranscriptiontumor suppressorZMAT3

Identifiers

PMID40391325
PMCPMC12087986

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.