Trial reportJournal of pain research2025
Effects of Intrathecal Sufentanil at Different Doses on Postoperative Pain Relief and Opioid Consumption in Elderly Patients Undergoing Lower Limb Orthopedic Surgery: A Randomized Controlled Trial.
Trial report in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and safety of intrathecal adjuvants in lower limb orthopaedic surgery: a systematic review and network meta-analysis of randomised controlled trials.Journal of anesthesia, analgesia and critical care · 2026Review
- Postoperative Delirium Following Continuous Fascia Iliaca Compartment Block in Elderly Patients with Hip Fracture: A Case Series and Literature Review.Local and regional anesthesia · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Fine-needle isobaric spinal anesthesia is preferred for elderly patients undergoing lower limb fracture surgery. However, single-agent local anesthetics are limited by short block duration, hemodynamic instability, and inadequate analgesia. Intrathecal sufentanil, as an adjunct, enhances analgesia, prolongs block duration, and promotes recovery. Yet, the dose-dependent effects of intrathecal sufentanil remain understudied. This study evaluates different doses of intrathecal sufentanil in this population, aiming to optimize dosing through evidence-based strategies. Methods: We randomly allocated 231 elderly patients into three groups: Group B (bupivacaine only), Group BS1 (bupivacaine + 5 μg sufentanil), and Group BS2 (bupivacaine + 10 μg sufentanil). We assessed baseline data, sensory and motor block characteristics, NRS scores, rescue opioid consumption, and complications. Results: BS1 and BS2 had delayed motor block onset (median = 3 min) compared to Group B (median = 2 min), but significantly longer motor block duration (BS2: 279.5 min, P = 0.001; BS1: 268.0 min, P = 0.022 vs Group B: 223.0 min). On postoperative day 2, BS1 and BS2 showed lower NRS scores and less analgesic use than Group B. Nausea was most common in BS1, while pruritus increased in BS2. Hypoxemia was highest in BS2 on postoperative day 1. Conclusion: Bupivacaine and sufentanil combined is a safe and effective regimen, prolonging analgesia and reducing postoperative pain and opioid use. BS2 (bupivacaine + 10 μg sufentanil) provided the best pain relief, ideal for high pain control needs, but higher pruritus and hypoxemia in BS2 suggest careful dosage adjustment based on patient tolerance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.