ArticleHealth science reports2025
Evaluation of Integrated Arterial Filter Oxygenator vs. External Arterial Filters on Clinical Outcomes and Neurocognitive Function in Pediatric Cardiac Surgery: A Prospective Randomized Controlled Trial (RCT).
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Progress in Understanding Brain Injury After Cardiopulmonary Bypass in Cardiac Surgery: A Narrative Review.Reviews in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Innovative advancements in cardiopulmonary bypass (CPB) configurations, such as surface coating, blood filtration, and miniaturization, aim to reduce gaseous microemboli (GME) that contribute to embolic organ damage, particularly neurological dysfunction. Arterial line filters are effective in mitigating embolism risk. Neurological complications post-cardiac surgery can result from reduced cerebral blood flow, embolic materials, and other factors, including anesthesia. This study evaluates the impact of integrated arterial filter oxygenator (IAF-Oxy.) versus external arterial filters (EAF) on clinical outcomes in pediatric patients undergoing surgery for congenital heart disease (CHD). Methods: This prospective randomized controlled trial included 100 pediatric patients undergoing cardiac surgery under CPB. Patients were randomized into two groups: Group A included external arterial filters (EAF) with membrane oxygenators such as Capiox Baby RX 05 and others, while Group B included integrated arterial filters (IAF) with oxygenators like Capiox Baby FX 05. The outcomes were neurological function, mechanical ventilation time (hours), intensive care unit stay (hours), and hospital stay (days). Results: Group B demonstrated significantly lower mean aortic cross-clamp (70.2 ± 38.5 vs. 88.0 ± 49.7 min; Conclusion: Integrated arterial filter oxygenator may serve as an alternative to external arterial filters, potentially reducing gaseous microemboli. IAF-Oxy. could improve clinical outcomes, reduce CSICU and hospital stays, and enhance care for pediatric congenital heart disease (CHD) patients.
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