Evidence map›Paper›PMID 40391231›Full record

ArticleJournal of inflammation research2025

CXCL1 and CXCL2: Key Regulators of Host Defense Against

Jiejie Lu, Qi Dong, Ruijun Zhang, Weiwei Wu, Huilan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiejie Lu *The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Qi Dong *Department of Dermatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, People's Republic of China.
Ruijun ZhangDepartment of Dermatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, People's Republic of China.ORCID 0000-0002-2881-4458
Weiwei WuDepartment of Dermatology, The Fifth People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.ORCID 0000-0001-5029-6936
Huilan YangThe First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Dematiaceous fungi, such as Methods: A subcutaneous infection model was employed, in which live Results: The current results show that both CXCL1 and CXCL2 deficiencies impair fungal clearance, leading to prolonged infection as evidenced by higher fungal loads and histopathology in Conclusion: These findings highlight the critical roles of CXCL1 and CXCL2 in mounting an effective immune response against dematiaceous fungi and suggest their potential as therapeutic targets.

Indexed as

CXCL1CXCL2immune responsePhialophora verrucosa

Identifiers

PMID40391231
PMCPMC12087586

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.