Evidence map›Paper›PMID 40391223›Full record

ArticleFrontiers in immunology2025

Protective effects of

Caiyi Yuan, Qiang Wang, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Hongxia Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caiyi Yuan *School of Public Health, Nanjing Medical University, Nanjing, China.
Qiang Wang *National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasitic and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Yuying Chen *School of Public Health, Nanjing Medical University, Nanjing, China.
Xin DingNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasitic and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Qiang ZhangNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasitic and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Jiakai YaoNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasitic and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Bei ZhangNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasitic and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Yang DaiSchool of Public Health, Nanjing Medical University, Nanjing, China.
Hongxia BaiDepartment of Science and Education, Xishan People's Hospital of Wuxi City, Wuxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Inflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology. The exploration of novel intervention strategies remains a key scientific issue that is urgently needed for IBD treatment. The hygiene hypothesis has led researchers to notice that worm infections can regulate the immune system, which might help treat inflammatory diseases. Methods: In this study, we established the protective and anti-inflammation effect of Nb infection and ES intervention in TNBS-induced IBD model in mice and further validated the efficiency of uridine screened from ES. Moreover, we conducted an RNA sequencing (RNA-Seq) analysis to elucidate the relevant possible functional mechanisms responsible for the protective and anti-inflammation effects of ES or uridine administration. Results: Current results have demonstrated that uridine can exhibit a protective effect on TNBS-induced IBD in mice. Moreover, it was identified that Discussion: The current study has illustrated that uridine is capable of exerting potential therapeutic and anti-inflammatory effects on Inflammatory Bowel Disease (IBD) by modulating

Indexed as

Anti-Inflammatory AgentsInflammatory Bowel DiseasesNippostrongylusOrganic Anion Transporters, Sodium-DependentStrongylida InfectionsSymportersUridineAnimalsDisease Models, AnimalMaleMiceTrinitrobenzenesulfonic AcidAnti-Inflammatory AgentsOrganic Anion Transporters, Sodium-Dependentsodium-bile acid cotransporterSymportersTrinitrobenzenesulfonic AcidUridineapical sodium-dependent bile acid transporterinflammatory bowel diseaseNippostrongylus brasiliensisRNA sequencinguridine

Identifiers

PMID40391223
PMCPMC12087013

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.