Evidence map›Paper›PMID 40391221›Full record

ArticleFrontiers in immunology2025

TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization.

Beiping Miao, Lihua Mo, Shihan Miao, Xiwen Zhang, Haoyue Zheng, Yixuan Dong, Bailing Xie, Yuanyi Zhang, Yun Liao, Yu Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. METTL5 in physiology and pathology: mechanisms and implications.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Beiping MiaoDepartment of Otolaryngology, Head & Neck Surgery, Shenzhen Second People's Hospital and Shenzhen Clinical Medical Research Center for Otolaryngology Diseases, Shenzhen, China.
Lihua MoDepartment of General Practice Medicine, Third Affiliated Hospital of Shenzhen University and Luohu Clinical College of Shantou University Medical College, Shenzhen, China.
Shihan MiaoDepartment of Otolaryngology, Head & Neck Surgery, Shenzhen Second People's Hospital and Shenzhen Clinical Medical Research Center for Otolaryngology Diseases, Shenzhen, China.
Xiwen ZhangState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.
Haoyue ZhengState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.
Yixuan DongState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.
Bailing XieDepartment of Otolaryngology, Head & Neck Surgery, Shenzhen Second People's Hospital and Shenzhen Clinical Medical Research Center for Otolaryngology Diseases, Shenzhen, China.
Yuanyi ZhangDepartment of Immunology & Key Laboratory of Tropical Translational Medicine of Ministry of Education & Department of Immunology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China.
Yun LiaoDepartment of General Practice Medicine, Third Affiliated Hospital of Shenzhen University and Luohu Clinical College of Shantou University Medical College, Shenzhen, China.
Yu LiuDepartment of General Practice Medicine, Third Affiliated Hospital of Shenzhen University and Luohu Clinical College of Shantou University Medical College, Shenzhen, China.
Ping TangDepartment of General Practice Medicine, Third Affiliated Hospital of Shenzhen University and Luohu Clinical College of Shantou University Medical College, Shenzhen, China.
Pingchang YangState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Th2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation of its mechanism is necessary. The immune cells of patients with immune diseases have been found to have abnormal epigenetic status. This research intends to examine the role of methyltransferase-like 5 (Mettl5) in regulating homeostasis in CD4 Methods: An AA mouse model was established with dust mite extracts as a specific antigen. The epigenetic marks in the Results: Spontaneous airway Th2 polarization was observed in mice carrying Mettl5-deficient CD4 Conclusions: Low Mettl5 levels in airway CD4

Indexed as

MethyltransferasesRespiratory HypersensitivityTh2 CellsTripartite Motif-Containing Protein 28AnimalsDisease Models, AnimalGATA3 Transcription FactorMiceMice, Inbred C57BLMice, KnockoutUbiquitinationGata3 protein, mouseGATA3 Transcription FactorMethyltransferasesTripartite Motif-Containing Protein 28allergyGATA3immunityinflammationth2

Identifiers

PMID40391221
PMCPMC12086080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.