Evidence map›Paper›PMID 40391185›Full record

ArticleBrain communications2025

Sex differences in story recall decline in preclinical Alzheimer's disease.

Douglas Cowman, Rebecca Langhough, Hayley Olson, Kristin Basche, Leah Sanson-Miles, Davide Bruno, Bruce Hermann, Bradley T Christian, Tobey J Betthauser, Sterling C Johnson and 1 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Elevated temporal tau PET predicts faster cognitive decline in women than men: A meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Pooled it
  2. A multiverse analysis of the logical memory test and plasma biomarkers of Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Douglas CowmanDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI 53792, USA.
Rebecca LanghoughWisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Hayley OlsonDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI 53792, USA.
Kristin BascheDivision of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53726, USA.ORCID https://orcid.org/0000-0001-5767-8507
Leah Sanson-MilesDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI 53792, USA.
Davide BrunoSchool of Psychology, Liverpool John Moores University, Liverpool L3 3AF, UK.
Bruce HermannWisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.ORCID https://orcid.org/0000-0003-0133-4427
Bradley T ChristianWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Tobey J BetthauserWisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.ORCID https://orcid.org/0000-0001-8856-1352
Sterling C JohnsonWisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Kimberly D MuellerDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID https://orcid.org/0000-0001-8691-9517

Funding

Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
Novel Story Recall Measures as Indicators of Cognitive Decline Associated with Alzheimer's Disease and Related Disorders Biomarkers: A Collaborative Study of Existing DataR01AG070940 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Kimberly D Mueller · 2021 to 2026
$2.8M
Biograph Horizon PET/CTS10OD025245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTIAN, BRADLEY T · 2018 to 2018
$1.3M
NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG054059NIA NIH HHS R01 AG070940NIH HHS S10 OD025245
6 · The paper itself

Abstract

Stage II pre-clinical Alzheimer's disease is defined by the presence of increased amyloid-beta evidenced by fluid and/or imaging biomarkers, in the absence of clinical signs and symptoms. Previous research suggests that pre-clinical sex differences exist on measures of story recall, such as the Wechsler memory scale-revised logical memory test total score. However, sex differences on a composite metric of proper names from that test have not been investigated, and the relationships between sex and amyloid positivity on longitudinal logical memory measures are unclear. We examined longitudinal trajectories of total score and proper names by sex (Aim 1), and by the combination of sex and amyloid status (Aim 2).

Indexed as

Alzheimer’s diseaseamyloid-betalanguagememorysex

Identifiers

PMID40391185
PMCPMC12086310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.