Evidence map›Paper›PMID 40391091›Full record

ArticleEndocrine oncology (Bristol, England)2025

Characterisation of a

Aqfan Jamaluddin, Rachael Wyatt, Andreea Pasaliu, Oliver Ruggles, Davide Calebiro, Caroline M Gorvin, Cristina L Ronchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine oncology (Bristol, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aqfan JamaluddinDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.
Rachael WyattDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.
Andreea PasaliuDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.
Oliver RugglesDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.
Davide CalebiroDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.
Caroline M GorvinDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.ORCID https://orcid.org/0000-0002-1361-9174
Cristina L RonchiDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.ORCID https://orcid.org/0000-0001-5020-2071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Adrenocortical adenomas are frequent in the general population and can be associated with autonomous cortisol excess, increasing morbidity and mortality. Altered cAMP/PKA signalling is common in sporadic cortisol-producing adenomas, typically due to somatic activating mutations in the catalytic subunit α of PKA ( Design and methods: Using HEK293 cells depleted of Results: The Gα Conclusions: In conclusion, our study demonstrated that the Gα

Indexed as

ACTH receptorcAMP/PKA signallingcortisol-producing adenomasG proteinsomatic mutation

Identifiers

PMID40391091
PMCPMC12087278

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.