Evidence map›Paper›PMID 40391085›Full record

ArticleNAR genomics and bioinformatics2025

dsRNAmax: a multi-target chimeric dsRNA designer for safe and effective crop protection.

Stephen J Fletcher, Jai Lawrence, Anne Sawyer, Narelle Manzie, Donald M Gardiner, Neena Mitter, Christopher A Brosnan

Abstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Recent Advances in Pathogenicity and Biocontrol of PostharvestJournal of fungi (Basel, Switzerland) · 2026
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephen J FletcherCentre for Horticultural Science, Queensland Alliance for Food and Agriculture Innovation, University of Queensland, St Lucia 4072, Queensland, Australia.ORCID https://orcid.org/0000-0002-7905-9325
Jai LawrenceCentre for Horticultural Science, Queensland Alliance for Food and Agriculture Innovation, University of Queensland, St Lucia 4072, Queensland, Australia.
Anne SawyerCentre for Horticultural Science, Queensland Alliance for Food and Agriculture Innovation, University of Queensland, St Lucia 4072, Queensland, Australia.
Narelle ManzieCentre for Horticultural Science, Queensland Alliance for Food and Agriculture Innovation, University of Queensland, St Lucia 4072, Queensland, Australia.
Donald M GardinerCentre for Horticultural Science, Queensland Alliance for Food and Agriculture Innovation, University of Queensland, St Lucia 4072, Queensland, Australia.
Neena MitterCentre for Horticultural Science, Queensland Alliance for Food and Agriculture Innovation, University of Queensland, St Lucia 4072, Queensland, Australia.
Christopher A BrosnanCentre for Horticultural Science, Queensland Alliance for Food and Agriculture Innovation, University of Queensland, St Lucia 4072, Queensland, Australia.ORCID https://orcid.org/0000-0002-6589-985X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crop protection is undergoing significant evolution, transitioning towards sustainable approaches that minimize impacts on the environment and human health. Exogenous application of double-stranded RNA (dsRNA) that silences pest or pathogen genes via RNA interference (RNAi) has promise as a safe and effective next-generation crop protection platform without the need for genetic modification. However, exogenous dsRNA application at scale presents challenges. Specifically, a single dsRNA sequence needs to balance targeting the standing variation in a target pest or pathogen group against the potential for adverse impacts in a vast array of non-target and beneficial organisms at the application site and broader environment. To address these competing demands, we present dsRNAmax (https://github.com/sfletc/dsRNAmax), a software package that employs

Indexed as

Crop ProtectionCrops, AgriculturalRNA, Double-StrandedSoftwareAnimalsRNA InterferenceRNA, Double-Stranded

Identifiers

PMID40391085
PMCPMC12086532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.