Evidence map›Paper›PMID 40391048›Full record

ArticleFrontiers in cellular and infection microbiology2025

Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in

Lijun Zheng, Yubo Dong, Jing Wang, Yonghui Jia, Weifang Wang, Yi Xu, Liangsheng Guo

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. TargetingInternational journal of molecular sciences · 2025
    Article
  4. Dual adaptive strategies inFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lijun Zheng *Department of Ultrasound Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yubo Dong *Department of Pharmacy, The 960th Hospital of PLA, Jinan, China.
Jing WangDepartment of Pharmacy, Zibo Zhoucun People's Hospital, Zibo, China.
Yonghui JiaDepartment of Pharmacy, The 960th Hospital of PLA, Jinan, China.
Weifang WangJinzhou Medical University Graduate Training Base, The 960th Hospital of PLA, Jinan, China.
Yi XuDepartment of Pharmacy, The 960th Hospital of PLA, Jinan, China.
Liangsheng GuoDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antifungal resistance and tolerance are distinct responses exhibited by fungi when exposed to drugs. While considerable research has focused on azole tolerance in the human pathogen Objective: This study aims to conduct a comparative investigation of the adaptation of the model organism Methods: We performed experiments using laboratory strains of Results: Our results revealed that fluconazole tolerance is present in wild-type strains of Conclusion: Transcriptome analysis indicated that petites up-regulated efflux mechanisms while down-regulating most

Indexed as

Adaptation, PhysiologicalAntifungal AgentsCandida albicansDrug Resistance, FungalFluconazoleSaccharomyces cerevisiaeGene Expression ProfilingGene Expression Regulation, FungalMicrobial Sensitivity TestsTemperatureAntifungal AgentsFluconazoleeffluxergosterolfluconazole tolerancepetiteSaccharomyces cerevisiae

Identifiers

PMID40391048
PMCPMC12086170

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.