Evidence map›Paper›PMID 40391040›Full record

ArticleClinical kidney journal2025

Incidence of cancer in people with CKD not requiring kidney replacement therapy: a systematic review and meta-analysis.

Benjamin M P Elyan, Beatrix Tan, Emilie Lambourg, David A McAllister, Rob J Jones, Ninian N Lang, Patrick B Mark, Jennifer S Lees, Samira Bell

Abstract read
In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin M P ElyanSchool of Cardiovascular and Metabolic Health, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, UK.
Beatrix TanRenal Unit, Ninewells Hospital, Dundee, UK.
Emilie LambourgDivision of Population Health and Genomics, Medical Research Institute, University of Dundee, Dundee, UK.
David A McAllisterSchool of Health & Wellbeing, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, UK.
Rob J JonesRenal Medicine, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, 1345 Govan Road, Glasgow, UK.
Ninian N LangSchool of Cardiovascular and Metabolic Health, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, UK.
Patrick B MarkSchool of Cardiovascular and Metabolic Health, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0003-3387-2123
Jennifer S LeesSchool of Cardiovascular and Metabolic Health, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0001-6331-0178
Samira BellRenal Unit, Ninewells Hospital, Dundee, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Cancer incidence in people with chronic kidney disease (CKD) who do not require kidney replacement therapy remains inadequately characterized. This systematic review aimed to establish whether there is an elevated incidence of cancer in people with CKD. Methods: A systematic search of three online bibliographic databases until 17 January 2023 identified studies reporting cancer incidence in CKD cohorts (PROSPERO CRD42022359690). Meta-analyses using inverse variance method compared incidence rates in individuals with low estimated glomerular filtration rate (eGFR) (<60 mL/min/1.73 m Results: In 27 studies (5 519 778 people with CKD), from 10 countries spanning 2009-2022, incidence rates of cancer were associated with worse CKD severity. Incidence rate ratio (IRR) comparing people with an eGFR <60 mL/min/1.73 m Conclusion: Individuals with CKD have an elevated incidence of cancer, with increasing age contributing to this association. These findings emphasize the importance of investigating whether CKD independently elevates cancer risk, building evidence for tailored cancer screening into CKD patient care.

Indexed as

cancer incidencechronic kidney diseaseonconephrologysystematic review

Identifiers

PMID40391040
PMCPMC12086533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.