ArticleJournal of obstetrics and gynaecology of India2025
Clinical Outcomes and Quality of Life in Children with Central Precocious Puberty: A Pragmatic Analysis.
Article in Journal of obstetrics and gynaecology of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Variable anthropometric and pubertal outcomes are reported in children with central precocious puberty (CPP) based on treatment choices and practices. We aimed to measure growth and pubertal progression in these children and associate with quality of life in relation to therapy received. Methods: This observational study enrolled children with CPP who were receiving/had received gonadotropin releasing hormone analog (GnRHa). The baseline and follow-up clinical details were recorded. Quality of life was assessed using PedsQL 4.0 at the last follow up visit. Results: Twenty-three children (21girls, 2 boys) with CPP, having a median (IQR) age of 6.75 (5.23, 8.25) years were enrolled. The mean (SD) height SDS was 0.45 (1.20) and BMI-SDS 0.65 (1.06). The median (IQR) follow-up duration was 4.4 (2.5-5.1) years. Twelve children completed their treatment and progressed through puberty normally.Mean bone age/chronological age (BA/CA) ratio decreased from baseline 1.46 to 1.23 at follow-up, Conclusion: Our study found favorable anthropometric outcomes with resumption of normal puberty after completion of GnRH therapy. The quality of life outcomes were favorable with early and adequate GnRH therapy.
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