Evidence map›Paper›PMID 40390864›Full record

ReviewRegenerative therapy2025

Research status of regenerative difficulties after central nervous system injury.

Yunxia Fu, Xi Rui, Shumin Zhu, Chenqu Guo, Haoyang Li, Zhenhao Pan, Xuanhao Wu, Wenpeng He

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. CaNeurochemical research · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunxia FuSchool of Stomatology, Jinan University, Guangzhou 510632, China.
Xi RuiHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Shumin ZhuHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Chenqu GuoSchool of Stomatology, Jinan University, Guangzhou 510632, China.
Haoyang LiSchool of Stomatology, Jinan University, Guangzhou 510632, China.
Zhenhao PanSchool of Stomatology, Jinan University, Guangzhou 510632, China.
Xuanhao WuSchool of Stomatology, Jinan University, Guangzhou 510632, China.
Wenpeng HeHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple studies have shown that permanent functional disabilities caused after nerve damage are mainly due to the limited ability of damaged neurons in the central nervous system (CNS) to regenerate axons and re-establish functional connections. Most axons in the CNS of adult mammals cannot reactivate their intrinsic growth program after injury, making axonal regeneration difficult when damaged. This article provides a systematic review of the response processes following CNS injury and the factors affecting repair and regeneration, focusing on the molecular mechanisms that regulate the regeneration of damaged axons, in hopes of offering new insights for the repair of CNS injuries.

Indexed as

Axon regenerationCentral nerve injuryGlial scarsMicrotubulePTEN

Identifiers

PMID40390864
PMCPMC12088777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.