ArticleFood science & nutrition2025
Vitamin D and Inhibition of Melanogenesis: Examination of Liposomal Vitamin D Nanocarrier Anti-Melanogenesis Activity on B16 F10 Cell Line.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Synergistic inhibitory effects of combined liposomal formulations of caffeic acid phenethyl ester and vitamin D on melanoma cell proliferation.Molecular biology reports · 2026Article
- Enhanced Stability and Bioavailability of Defatted Cricket Protein Hydrolysates Encapsulated in Alginate-Coated Liposomes.Foods (Basel, Switzerland) · 2026Article
- Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery Approaches.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite various treatment strategies employed thus far, malignant melanoma usually resists most of the interventions. The present work is an attempt to synthesize liposomes encapsulating vitamin D, evaluate their physicochemical properties, evaluate the release kinetics of vitamin D, and examine the cytotoxicity of both liposomal and free vitamin D on melanoma cells in vitro. The analysis revealed that the zero-order model exhibited the best correlation (0.998) at acidic pH (5.5), indicating the most efficient vitamin D release from the nanoparticles. The results indicated that the IC50 values for cancer cells exposed to vitamin D-containing liposomes were 35.08 and 28.96 μg/mL after 24-48 h. Compared to those treated with free vitamin D, flow cytometry results further demonstrated a higher apoptosis in B16 F10 cells exposed to vitamin D-containing liposomes. Moreover, vitamin D-containing liposomes induced the most significant nanomechanical alterations, with the most pronounced decrease in the expression of the PI3K/AKT1 gene observed in the liposomal vitamin D treatment group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.