ArticleAlzheimer's & dementia (New York, N. Y.)
Dynamic neurocognitive adaptation: A follow-up exposome investigation in aging.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionForty-five percent of Alzheimer's disease (AD) cases may be preventable. Validated tools for measuring environmental factors, with precision equal to that of current biological and genetic assessment tools, are currently lacking.
methodsWe used the dynamic Neurocognitive Adaptation (dNA) scale, our validated tool to explore protective factors in AD, in 410 older adult participants (50% women). The dNA asks participants to recall cognitive, creative, physical, and social activities that they engaged in at seven different time periods in their lives. We examined associations among engagement in these domains using distance correlations and tested differences in domain engagement over time with repeated-measures analysis of variance. We calculated within-subjects comparisons for time and all interactions among time, sex, and education. We examined between-subjects factors for sex, education, and their interaction. From these models, we constructed visualizations of estimated marginal means against time to assess potential patterns of interest.
resultsPhysical and creative domain engagements were significantly correlated ( DISCUSSION: Our scale provides new insight into the correlation of environmental factors with education, suggests areas for lifestyle intervention, and highlights the importance of sex differences and middle age as a potential transition stage. Highlights: Physical activity decreases and cognitive activity increases through time.Higher involvement in physical activities is correlated with creative and social dimensions.Men are more involved in physical and women in cognitive activities.Higher education is associated with higher involvement in all the dimensions explored.
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