Evidence map›Paper›PMID 40390807›Full record

ArticleJBMR plus2025

Differential contributions of lean and fat mass on bone mineral density in Asian women of reproductive age: the Singapore Preconception Study of Long-Term Maternal and Child Outcomes study.

Mya Thway Tint, Andrea Cremaschi, Melvin Khee Shing Leow, Natarajan Padmapriya, Seng Bin Ang, Jun Shi Lai, Jerry Kok Yen Chan, Jonathan Y Bernard, Peter D Gluckman, Yap-Seng Chong and 6 more

Abstract read
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mya Thway TintInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.ORCID https://orcid.org/0000-0002-9548-7186
Andrea CremaschiSchool of Science and Technology, IE University, 28006 Madrid, Spain.
Melvin Khee Shing LeowInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.
Natarajan PadmapriyaDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Seng Bin AngFamily Medicine Service, KK Women's and Children's Hospital, Singapore 229899, Singapore.
Jun Shi LaiInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.
Jerry Kok Yen ChanDepartment of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore 229899, Singapore.
Jonathan Y BernardCentre for Research in Epidemiology and StatisticS (CRESS), Université Paris Cité, Université Paris Centre Nord, Inserm, INRAE,  F-75004 Paris, France.
Peter D GluckmanInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.
Yap-Seng ChongInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.
Keith M GodfreyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, United Kingdom.ORCID https://orcid.org/0000-0003-3025-5269
Falk Müller-RiemenschneiderSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID https://orcid.org/0000-0003-1402-7477
Cuilin ZhangDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Nicholas C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, United Kingdom.ORCID https://orcid.org/0000-0002-8194-2512
Maria De IorioInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.
Johan G ErikssonInstitute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.ORCID https://orcid.org/0000-0002-2516-2060

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationships between fat mass (FM), lean mass (LM), and bone mass are complex with significant implications for obesity, sarcopenia, and osteoporosis later in life. While greater LM is associated with higher BMD, the association between FM and BMD is less clear. Such relationships warrant further investigation, especially in Asians, who have a higher risk of metabolic diseases and osteoporotic fractures compared to Western populations. This study investigated the associations of LM, FM, and modifiable risk factors with BMD in Asian women aged 18-45 yr. A total of 191 women from the Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) cohort study underwent DXA scanning at the first study visit for BMD and body composition measurements. LM, FM, and four body composition phenotypes derived from dichotomizing LM and FM were related to cohort-specific Z-scores of BMD at FN (BMD

Indexed as

Asian womengeneral population studieshuman association studieslean massosteoporosissarcopenia

Identifiers

PMID40390807
PMCPMC12087953

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.