ArticleOpen forum infectious diseases2025
Relationship Between Frailty and Respiratory Syncytial Virus Infection in Hospitalized Older Adults.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- An Appraisal of the Potential Downstream Benefits of RSV Vaccination in Older Adults.Reviews in medical virology · 2026Review
- Frailty Increases the Risk and Frequency of Lower Respiratory Tract Infections in Older Adults: A Multicenter Prospective Cohort Study.Open forum infectious diseases · 2026Article
- Incidence of Respiratory Syncytial Virus-Associated Hospitalization Among Adults in Ontario, Canada, 2017-2019.The Journal of infectious diseases · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to evaluate the impact of frailty on clinical outcomes and disease severity of respiratory syncytial virus (RSV) infection in older adults using data from the CIRN SOS Network (Serious Outcomes Surveillance Network; Canadian Immunization Research Network). Methods: This cohort study used data from the CIRN SOS Network collected during the 2012-2013, 2013-2014, and 2014-2015 influenza seasons. Patients aged ≥50 years who were hospitalized for acute respiratory illness were tested for RSV by multiplex reverse transcription-polymerase chain reaction. The analysis focused on frailty to assess its association with RSV disease severity and clinical outcomes. Frailty was categorized as Results: Among 365 older adults hospitalized for RSV-related acute respiratory infections, most were classified as frail (61.1%), with fewer classified as prefrail (28.5%) or nonfrail (10.4%). Frailty was significantly associated with severe RSV outcomes, such as prolonged hospitalization and increased oxygen therapy requirements. Specifically, frail patients experienced longer hospitalizations and higher intensive care unit admission rates, with an odds ratio of 3.48 (95% CI, 1.30-9.12) for the association between frailty and severe disease. While RSV types A and B showed no significant differences in clinical outcomes, chronic obstructive pulmonary disease and chronic kidney disease emerged as factors associated with disease severity, alongside frailty. Conclusions: Frailty is an important predictor of RSV severity in older adults and is associated with longer hospital stays and increased health care needs. This highlights the need to consider frailty in RSV vaccine and therapeutic trials and suggests the potential benefits of interventions and public health and programmatic messaging tailored to older adults living with frailty.
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