ReviewInternational journal of stroke : official journal of the International Stroke Society2025
Frailty and stroke: Global implications for assessment, research, and clinical care-A WSO scientific statement.
Review in International journal of stroke : official journal of the International Stroke Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment-modifying effects of frailty on stroke reperfusion therapy outcomes: a systematic review and meta-analysis.Age and ageing · 2026Pooled it
- A roadmap towards clinical use of molecular biomarkers in acute ischaemic stroke.Nature reviews. Neurology · 2026Review
- Co-evolving adiposity and frailty trajectories shape stroke risk in middle-aged and older adults.iScience · 2026Article
- Review
- Age-Related Brain Atrophy Mediates a Composite Outcome of One-Year Ischemic Stroke Recurrence and All-Cause Mortality Through YKL-40-Related Inflammatory Pathways: A Structural Equation Model.Translational stroke research · 2026Article
- Frailty Index and Risk of Ischemic Stroke in China: Evidence from a Cohort Study, Disease Burden Analysis, and Mendelian Randomization.Healthcare (Basel, Switzerland) · 2026Article
- The Association Between PIV and Mortality in US Stroke Survivors: A NHANES 1999-2018 Retrospective Cohort Study.Health science reports · 2026Article
- Associations of body mass index and metabolic health with stroke risk in a large prospective cohort with time updated covariates.Scientific reports · 2026Article
- Relationship between intrinsic capacity, physical resilience and frailty among older adults patients during stroke recovery: a cross-lagged panel study.BMC geriatrics · 2026Article
- Prediction model for frailty risk in ischemic stroke patients: Application and validation of support vector machines and nomograms.Medicine · 2026Article
- Endovascular treatment in patients with renal dysfunction: results of the MR CLEAN Registry.European stroke journal · 2026Observational
- A multimodal individualized long-term intervention to prevent functional decline after stroke (LAST-long): a single blinded randomised controlled trial.The Lancet regional health. Europe · 2026Article
- Frailty and Cardiovascular Risk.European cardiology · 2026Review
- Safety and Clinical Outcomes of Endovascular Thrombectomy in Very Elderly Patients (≥80 Years) with Acute Ischemic Stroke: A Prospective Multicenter Cohort Study in Vietnam.Clinical interventions in aging · 2026Article
- Developing and validating a frailty score based on patient-reported outcome 3 months after stroke: A Riksstroke-based study.PloS one · 2026Article
- Impact of frailty on rehabilitation exercise adherence in patients with ischemic stroke.Frontiers in medicine · 2025Article
- Dynamic frailty and depressive symptoms in relation to incident stroke: findings from five harmonized longitudinal cohorts.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty is common in stroke and has important disease- and treatment-modifying effects. The need to develop clinical practice and research for the impact of frailty on stroke is likely to increase in the coming decades as the global population ages, resulting in a higher burden of frailty that is likely to be borne disproportionately by lower- and middle-income countries.The global nature of frailty in stroke necessitates global action. This World Stroke Organization Scientific Statement synthesizes the current evidence relating to the prevalence and effects of frailty across the stroke pathway. Furthermore, it includes expert consensus on priority areas from a global panel: standardization of frailty assessments for research, explicit measurements of frailty (in addition to disability) in large clinical trials, dedicated studies investigating the treatment-modifying effects of frailty in acute stroke and secondary prevention, research investigating the impact of frailty on the different aspects of recovery and rehabilitation after stroke, and understanding the mechanisms underpinning the relationship between frailty and stroke for potential therapeutic exploitation.This scientific statement has been reviewed and approved by the World Stroke Organization Executive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.