Evidence map›Paper›PMID 40390578›Full record

ArticleActa biochimica et biophysica Sinica2025

A modified system to promote stemness of mouse intestinal stem cells by activating Nrf2 and α2-adrenergic receptor signaling pathway.

Xingyu Zhou, Li Yang, Sentao Song, Xiaolei Yin

Abstract read
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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xingyu ZhouInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Li YangInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Sentao SongDepartment of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200092, China.
Xiaolei YinInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal stem cells (ISCs) maintain epithelial homeostasis through continuous self-renewal and differentiation, but their regulatory mechanisms remain incompletely understood. Using a simplified culture system, we identify two novel pathways that synergistically enhance stem cell characteristics: antioxidant signaling through 2-phospho-L-ascorbic acid (pVc) and α2-adrenergic receptor (α2-AR) activation by dexmedetomidine (Dex). Mechanistic studies reveal that pVc promotes stem cell maintenance through Nrf2-mediated antioxidant responses, while α2-AR activation functions through suppression of cAMP signaling.

Indexed as

IntestinesNF-E2-Related Factor 2Receptors, Adrenergic, alpha-2Signal TransductionStem CellsAdrenergic alpha-2 Receptor AgonistsAnimalsAscorbic AcidCell DifferentiationCell ProliferationDexmedetomidineIntestinal MucosaMiceMice, Inbred C57BLAdrenergic alpha-2 Receptor AgonistsAscorbic AcidDexmedetomidineNfe2l2 protein, mouseNF-E2-Related Factor 2Receptors, Adrenergic, alpha-2cAMP signaling pathwayintestinal regenerationintestinal stem cellNrf2 signaling pathwayα2-adrenergic receptor

Identifiers

PMID40390578
PMCPMC13059766

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.