ArticleNature
Diacylglycerol in large alpha-actinin/actin complexes and in the cytoskeleton of activated platelets.
Article in Nature. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 148 citations in OpenAlex.
- The Importance of Alpha-Actinin Proteins in Platelet Formation and Function, and Their Causative Role in Congenital Macrothrombocytopenia.International journal of molecular sciences · 2021Review
- Up-regulation of AKAP13 and MAGT1 on cytoplasmic membrane in progressive hepatocellular carcinoma: a novel target for prognosis.International journal of clinical and experimental pathology · 2015Article
- Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.The Journal of clinical investigation · 2008Article
- Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data.Theoretical biology & medical modelling · 2006Article
- Phospholipase D activity is required for actin stress fiber formation in fibroblasts.Molecular and cellular biology · 2001Article
- The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism.The EMBO journal · 2000Article
- Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns (3,4,5)-p(3) binding to alpha-actinin.The Journal of cell biology · 2000Article
- Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments.The Journal of cell biology · 2000Article
- The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.Oncogene · 2000Article
- Nuclear lipid metabolism in NEST: Nuclear Envelope Signal Transduction.The Journal of membrane biology · 1994Review
- Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension.The Journal of cell biology · 1994Article
- Actin binding to lipid-inserted alpha-actinin.Biophysical journal · 1993Article
- Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.The Journal of cell biology · 1992Article
- Incorporation of lipids labeled with various fatty acids into the cytoskeleton of aggregating platelets.Lipids · 1991Article
- Actin binding proteins--lipid interactions.Journal of muscle research and cell motility · 1991Review
- A protein kinase C isozyme is translocated to cytoskeletal elements on activation.Cell regulation · 1990Article
- Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.American journal of human genetics · 1990Article
- Palmitic acid-labeled lipids selectively incorporated into platelet cytoskeleton during aggregation.Lipids · 1990Article
- Bundling of actin filaments by alpha-actinin depends on its molecular length.The Journal of cell biology · 1990Article
- Gelsolin-actin interaction and actin polymerization in human neutrophils.The Journal of cell biology · 1990Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction of the cytoskeleton with plasma membranes may be mediated by vinculin, alpha-actinin and other proteins; alpha-actinin can interact specifically with model membranes only if they contain diacylglycerol and palmitic acid. On stimulation of platelets by thrombin, which leads to a reorganization of the cytoskeleton, diacylglycerol is produced rapidly, simultaneously with the disappearance of phosphatidylinositol. One important function of the diacylglycerol produced in platelets may be the activation of the Ca2+-and phospholipid-dependent protein kinase C. We show here that, in the presence of diacylglycerol and palmitic acid, a supramolecular complex between alpha-actinin and actin is formed in vitro. In the electron microscope, this complex displays substructures similar to those of microfilament bundles in vivo. Furthermore, such alpha-actinin/lipid complexes can also be formed in situ during the stimulation of blood platelet aggregation. Thus, alpha-actinin may be one of the proteins directly involved in structures connecting the cytoskeleton to cell membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.