ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Sleep macro-architecture, nocturnal hypoxemia, and Alzheimer's disease-related MRI patterns among diverse older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Noninvasive Electrophysiological Biomarkers of Olfactory Responses Across Cognitive States in Alzheimer Dementia: Cross-Sectional Study.JMIR mHealth and uHealth · 2026Article
- REM Sleep is Associated with Cognition and Biomarkers Longitudinally in Older Adults Across the Alzheimer Disease Continuum.medRxiv : the preprint server for health sciences · 2026Article
- Sleep macro-architecture, nocturnal hypoxemia, and Alzheimer's disease-related MRI patterns among diverse older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
introductionSleep patterns change with aging, yet their relationship with brain health, particularly Alzheimer's disease (AD)-related MRI patterns among diverse older adults is not clear.
methodsWe cross-sectionally studied community-dwelling Non-Hispanic White (NHW), Hispanic, and Black participants recruited from the Health and Aging Brain Study-Health Disparities (HABS-HD)-Dormir Study, who underwent WatchPAT and brain MRI.
resultsA total of 842 participants (34% male; 42% NHW, 33% Hispanic, and 25% Black; mean age 66.1 ± 8.6 years) were included. Greater light sleep percentage and longer rapid-eye movement (REM) sleep latency were independently associated with thinner cortex in AD-signature regions, while inverse pattern was observed for greater deep sleep percentage. Higher Apnea-Hypopnea Index (AHI) in REM sleep was independently associated with greater white matter hyperintensities volume. There were no ethnoracial interactions for these associations. DISCUSSION: Light and deep sleep percentage, REM sleep latency, and AHI in REM sleep were associated with AD-related MRI patterns. HIGHLIGHTS: Greater light sleep percentage and longer rapid-eye movement sleep latency were associated with thinner cortex in the Alzheimer's Disease-siganture regions, while greater deep sleep percentage was associated with thicker cortex in those regions. Higher apnea hypoonea index in rapid eye movement sleep was associated with greater white matter hyperintensities volume. No moderation effects by race/ethnicity were observed among Non-Hispanic White/Hispanic/Black adults.
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