Evidence map›Paper›PMID 40390225›Full record

Trial reportCurrent pharmaceutical design2025

A Split-Mouth, Randomized, Double-Blind Clinical Trial of a Gelatin Hemostatic Dental Sponge Containing Aloe Vera Nanoparticles for Controlling Bleeding After Mandibular Posterior Teeth Extraction.

Amir Zandesh, Mahsa Mehrpouya, Paniz Panahi, Naeimeh Motallebi, Simin Sharifi, Solmaz Maleki Dizaj, Mohammad Ali Ghavimi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amir ZandeshDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahsa MehrpouyaDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Paniz PanahiDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Naeimeh MotallebiDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Simin SharifiDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Solmaz Maleki DizajDepartment of Dental Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Ali GhavimiDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

Vice Chancellor for Research at Tabriz University of Medical Sciences 71406
6 · The paper itself

Abstract

introductionHemostatic dental sponges are biodegradable materials and fast hemostats that can help blood clotting in the surgical site and quick repair of the dental surgery site. In this study, we investigated the bleeding control (blood absorption ability and active bleeding) of a hemostatic gelatin sponge containing aloe vera nanoparticles as a hemostatic material after the removal of mandibular posterior teeth in a doubleblind, randomized trial.

methodsA clinical trial was performed on 30 patients (13 males and 17 females) who were referred to the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, for extraction of two mandibular molars. The plan was a split-mouth, randomized, double-blind clinical trial. To investigate the blood absorption ability of a hemostatic sponge containing aloe vera nanoparticles in each patient after tooth extraction, the sponge was placed in the socket of the extracted tooth. Sterile gauze was placed on the hemostat sponge containing aloe vera nanoparticles (test group). For the control group, the same process was repeated with a sponge without aloe vera nanoparticles. The number of used sterile gauzes was recorded and the mean excess blood weight was measured with a digital scale. Also, the amount of bleeding after 1 and 4 hours of tooth extraction was recorded for all patients as an active bleeding time.

resultsThe number of sterile gauzes used and the mean excess blood weight used in each group indicate blood absorption. The results showed that there was no significant difference in the amount of sterile gauze between the two groups (P=0.65). In both groups, the consumption of three sterile gauzes was the most frequent. However, the mean excess blood weight in the control group was significantly higher, which indicates the better efficiency of the test group (P=0.04). Besides, the examination of the patients showed that in none of the patients of the two groups, active bleeding was observed 1 and 4 hours after tooth extraction.

conclusionThe performance of the test sponge was better than the control sponge in controlling bleeding after tooth extraction. It seems that the obtained results cannot only be related to the presence of aloe vera nanoparticles. The differences in the bleeding control (blood absorption ability and the active bleeding time) for the used sponges can also influence the results. In addition, the use of aloe vera in the form of nanoparticles can contribute to early healing effects and other beneficial effects, such as antimicrobial effects in the toothextracted site.

Indexed as

AloeGelatinGelatin Sponge, AbsorbableHemostaticsNanoparticlesPostoperative HemorrhageTooth ExtractionAdultDouble-Blind MethodFemaleHumansMaleMandibleMiddle AgedMolarYoung AdultGelatinHemostaticsaloe veragelatinHemostatnanoparticlesspongetooth extraction.

Identifiers

PMID40390225

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.