ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Beyond binary classification: Comparing three region-based multi-phase Aβ staging systems.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Spatial amyloid-informed multimodal brain age as an early marker of Alzheimer's-related vulnerability and risk stratification.The journal of prevention of Alzheimer's disease · 2026Article
- Subjective sleep characteristics in non-demented adults: domain-specific associations with multimodal Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Beyond binary classification: Comparing three region-based multi-phase Aβ staging systems.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- MALT1 in cerebrospinal fluid: a prognostic biomarker and potential therapeutic target in Alzheimer's disease.Frontiers in neurology · 2025Article
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Authors and funding
10 authors.
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Abstract
introductionThis study aims to establish a multi-phase visual staging system based on amyloid-beta (Aβ) deposition to more precisely assess the stages of Aβ accumulation in Alzheimer's disease (AD), and to validate the cognitive function, neurodegeneration, and blood biomarker characteristics at different stages.
methodsA total of 1002 participants from the Chinese Preclinical Alzheimer's Disease Study (C-PAS) cohort were included. Aβ deposition was assessed using positron emission tomography (PET) imaging, and three multi-phase Aβ deposition grading systems were established. Participants underwent neuropsychological testing, peripheral blood biomarker collection, and multimodal neuroimaging data acquisition.
resultsCognitive function, peripheral blood biomarkers, default mode network (DMN) function, and hippocampal volumes showed stage-dependent changes across different Aβ deposition stages. Different grading systems revealed varying clinical manifestations and biomarker sensitivity. DISCUSSION: Region-based multi-phase Aβ deposition systems demonstrate practical utility in detecting early pathological changes, understanding disease progression, and informing early diagnosis and intervention strategies for AD. HIGHLIGHTS: Developed and validated visual multi-phase Aβ deposition staging systems for AD progression. Revealed stage-specific cognitive, neurodegenerative, and biomarker characteristics in AD. Demonstrated the sensitivity of visual methods to detect early, regional Aβ deposition. Highlighted differential strengths of Villeneuve, Grothe, and Mattsson staging systems. Proposed multi-phase systems as tools for personalized AD diagnosis and intervention strategies.
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