Evidence map›Paper›PMID 40390195›Full record

ArticlePediatric blood & cancer2025

Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series.

Michael R Sargen, Madeline H Fitzhugh, Jennifer S Ko, Allison G Close, Sara C Horton, Faizan Malik, Larissa V Furtado, Armita Bahrami, Brittani K N Seynnaeve, Alberto S Pappo and 21 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Michael R SargenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0003-1039-2522
Madeline H FitzhughDepartment of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.ORCID https://orcid.org/0009-0006-2825-8005
Jennifer S KoDepartment of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.
Allison G CloseDepartment of Hematology-Oncology, Helen DeVos Children's Hospital, Grand Rapids, Michigan, USA.ORCID https://orcid.org/0000-0002-0976-4723
Sara C HortonDepartment of Hematology-Oncology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
Faizan MalikDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Larissa V FurtadoDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Armita BahramiDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Brittani K N SeynnaeveDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-5011-7678
Alberto S PappoDepartment of Oncology, St. Jude's Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-5338-3979
Vincent LiuDepartment of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Kevin CheungDepartment of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0002-0048-5576
Svetlana D PackLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Liqiang XiLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Mark RaffeldLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Ina LeeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Jeffrey GaganLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kenneth AldapeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Frederic G BarrLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Stephen M HewittLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Christina K FerroneLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Anna HaydenDivision of Dermatology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Jessica N HattonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.
Brigitte WidemannPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Mary Frances Wedekind MalonePediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-9707-7175
Andrea M GrossPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-1646-4531
Rosandra KaplanPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Marielle E YoheLaboratory of Cell and Developmental Signaling, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Kristen G BerrebiDepartment of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Funding

Intramural NIH HHS Z99 CA999999Intramural Research Program of the Division of Cancer Epidemiology and Genetics and the Center for Cancer ResearchNCI NIH HHSNIH HHS
6 · The paper itself

Abstract

Limited information is available on the clinicopathologic features and management of pediatric CRTC1::TRIM11 (CTRTs) and MED15::ATF1-rearranged tumors (MARTs). In this series of pediatric CTRTs (n = 5) and MARTs (n = 2), all tumors exhibited spitzoid morphology and expressed melanocytic markers. Metastatic progression occurred in one CTRT and two MARTs: all three received immunotherapy, resulting in disease control in two patients and one death due to progressive disease. A fourth individual had lymph node micrometastasis that remained stable without progression. This case series highlights the potentially aggressive behavior of these tumors and suggests that immunotherapy may be an effective treatment option for advanced disease.

Indexed as

Nevus, Epithelioid and Spindle CellSkin NeoplasmsTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesAdolescentChildChild, PreschoolFemaleHumansImmunotherapyMalePrognosisCRTC1 protein, humanTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesCRTC1::TRIM11 fusionimmunotherapyMED15::ATF1 fusionmelanomaSpitzspitzoid

Identifiers

PMID40390195
PMCPMC13389253

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.