Evidence map›Paper›PMID 40390192›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Reengineering of a Proteomimetic Pan-Ras Inhibitor into a Ras Degrader.

Joseph F Ongkingco, Seong Ho Hong, Eugene D Toth, Thu Nguyen, Paramjit S Arora

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation.Journal of the American Chemical Society · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph F Ongkingco *Department of Chemistry, New York University, 100 Washington Square East, New York, NY, 10003, USA.
Seong Ho Hong *Department of Chemistry, New York University, 100 Washington Square East, New York, NY, 10003, USA.
Eugene D TothDepartment of Chemistry, New York University, 100 Washington Square East, New York, NY, 10003, USA.
Thu NguyenDepartment of Chemistry, New York University, 100 Washington Square East, New York, NY, 10003, USA.
Paramjit S AroraDepartment of Chemistry, New York University, 100 Washington Square East, New York, NY, 10003, USA.ORCID 0000-0001-5315-401X

Funding

Protein Domain Mimics as Modulators of Biomolecular InteractionsR35GM130333 · NIGMS · NEW YORK UNIVERSITY · PI Paramjit S Arora · 2019 to 2026
$6.0M
NIGMS NIH HHS R35 GM130333NIH HHS R35GM130333
6 · The paper itself

Abstract

Bifunctional ligands that can coax protein-protein interactions have become attractive therapeutic modalities. Herein, we describe conformationally defined helix dimers as proteomimetic molecular glues. The helix dimers can be rationally designed to engage helical protein interfaces. We previously described a synthetic Sos protein mimic, CHD

Indexed as

ras ProteinsHumansProtein EngineeringProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-mdm2ras ProteinsConstrained peptidesMolecular gluesProtein–protein interactionsProteomimeticsRas

Identifiers

PMID40390192
PMCPMC12283227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.