Evidence map›Paper›PMID 40390143›Full record

Trial reportHereditas2025

Efficacy of red ointment in wound cavity repair following non-puerperal mastitis debridement.

Jiamei Feng, Zheng Chen, Jiaye Sun, Shijun Shao, Lu Xie, Wenchao Qu, Qingqian Gao, Xueqing Wu, Hua Wan

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Hereditas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiamei Feng *Department of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China.
Zheng Chen *Department of Traditional Chinese Medicine, Yichuan Street Community Health Service Center, Putuo District, Shanghai, 200065, China.
Jiaye SunDepartment of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China.
Shijun ShaoDepartment of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China.
Lu XieDepartment of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China.
Wenchao QuDepartment of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China.
Qingqian GaoDepartment of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China.
Xueqing WuDepartment of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China. wuxueqingwxq02@126.com.
Hua WanDepartment of Mammary, Shuguang Hospital, Shanghai University of Tradition Chinese Medicine, No.185 Pu 'an Road, Huangpu District, Shanghai, 200011, China. wanhuawhhhf@126.com.

Funding

Shanghai Municipal Health Commission research project 202040254Shanghai Science and Technology Commission research program 19401934000
6 · The paper itself

Abstract

backgroundThe objective of this study is to evaluate the efficacy of red ointment, a widely used topical agent in traditional Chinese medicine, in promoting wound cavity repair following debridement for non-puerperal mastitis (NPM).

methodsA prospective, randomized controlled trial was conducted, including 88 patients diagnosed with NPM. Patients were randomly assigned to either the treatment group or the control group. All patients underwent debridement during the acute inflammatory phase. Postoperatively, the treatment group received daily dressing changes using sterile gauze strips infused with red ointment, whereas the control group received sterile gauze strips soaked in rivanol. The effectiveness of treatment was assessed after two weeks by evaluating the total effective rate, wound cavity score, symptom and sign score, laboratory parameters, and adverse events.

resultsIn the intention to treat analysis, the total effective rate was 90.9% in the red ointment group, which was higher than the 86.4% observed in the rivanol group. In the per protocol analysis, the total effective rate was 97.6% in the red ointment group, exceeding the 92.7% in the rivanol group. Compared with rivanol-treated gauze strips, the use of red ointment gauze strips resulted in a significantly greater reduction in wound cavity volume (p < 0.05), improved local breast symptoms (p < 0.05), and a lower wound cavity score (p < 0.001). Granulation tissue in the red ointment group exhibited a significantly fresher color compared to the rivanol group (p < 0.05). No significant differences were observed between the two groups regarding adverse effects on hepatic and renal function following treatment.

conclusionThe use of red ointment gauze strips for wound cavity filling following NPM debridement demonstrated favorable clinical efficacy and safety, providing a viable option for postoperative drainage management.

Indexed as

DebridementMastitisWound HealingAdultFemaleHumansMiddle AgedOintmentsProspective StudiesTreatment OutcomeOintmentsEfficacyNon-puerperal mastitisRed ointmentWound cavity repair

Identifiers

PMID40390143
PMCPMC12087160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.