ArticleItalian journal of pediatrics2025
Clinical characteristics and post-operative outcomes in children with purulent meningitis with hydrocephalus: 46 cases in a single center study.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo investigate the clinical characteristics, surgical strategy, and surgical outcomes in children with purulent meningitis with hydrocephalus (PMH) under 3 years old.
methodsThis retrospective controlled study included 46 pediatric patients who underwent the Conventional external ventricular drain (C-EVD) or modified external ventricular drainage (M-EVD) for PMH treatment at Hebei Province of Children's Hospital from January 2018 to December 2023. Conventional external ventricular drain placement is standard of care in the management of purulent meningitis with hydrocephalus. The indwelling time of conventional external ventricular drainage is relatively short, 7-10 days. Long-term external drainage devices may lead to retrograde infection. This study has modified the external ventricular drain procedure. Clinical outcomes, cerebrospinal fluid (CSF) test results, complications, and outcomes were compared between the modified external ventricular drainage (n = 21) group and conventional external ventricular drain (n = 25) group.
resultsThe two groups were similar regarding age, sex, weight and other general conditions (P > 0.05). There were significant differences in the values of white blood cells (WBC), glucose (GLU) and protein (PR) in cerebrospinal fluid between the two groups when the drainage tube was removed, which was statistically significant. The median days of removing the drainage tube in the conventional external ventricular drain group and the modified external ventricular drainage group were 9 days and 19 days, respectively. The median days of CSF returning to normal were 19 days and 13 days (P < 0.05). A total of 13 children in the modified external ventricular drainage group underwent ventriculo-peritoneal shunt surgery, while 17 children in the conventional external ventricular drain group were treated with entriculo-peritoneal shunt surgery (P = 0.665).
conclusionThe modified external ventricular drainage has more obvious advantages compared to conventional external ventricular drain. The modified significantly prolonged the catheterization time, which can more effectively treat purulent meningitis with hydrocephalus in pediatric patients.
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