Evidence map›Paper›PMID 40390110›Full record

ArticleEcho research and practice2025

Standing transthoracic echocardiography: a feasibility study.

Stephen P Juraschek, Noelle Ojo, Janet Monroe, Jordan B Strom, Jessica Stout, Warren J Manning, Ruth-Alma N Turkson-Ocran, Gabrielle Kolaci, Kaitlynn Geier, Carla Baptista and 3 more

Abstract read
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In one paragraph

Article in Echo research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stephen P JuraschekDivision of General Medicine, Section for Research, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, CO-1309, #217, Boston, MA, 02215, USA. sjurasch@bidmc.harvard.edu.
Noelle OjoDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Janet MonroeDivision of General Medicine, Section for Research, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, CO-1309, #217, Boston, MA, 02215, USA.
Jordan B StromRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jessica StoutDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Warren J ManningDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Ruth-Alma N Turkson-OcranDivision of General Medicine, Section for Research, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, CO-1309, #217, Boston, MA, 02215, USA.
Gabrielle KolaciDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Kaitlynn GeierDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Carla BaptistaDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Araina PicanzoDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Kenneth J MukamalDivision of General Medicine, Section for Research, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, CO-1309, #217, Boston, MA, 02215, USA.
Jason D MatosDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Funding

Clinical Implications of Blood Pressure Patterns Among Older AdultsR01HL153191 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2021 to 2023
$2.3M
NHBLI R01HL153191NHLBI NIH HHS R01 HL153191
6 · The paper itself

Abstract

backgroundOrthostatic hypotension (OH) is associated with cardiovascular disease, particularly among older adults. While a standing transthoracic echocardiogram (TTE) could theoretically identify changes in cardiac output to diagnose cardiogenic OH, there are no established protocols for orthostatic TTEs and their feasibility is unknown. METHODS AND

resultsWe recruited 115 patients scheduled for elective outpatient TTE. Consenting participants, who were able to stand safely, underwent their scheduled recumbent TTE, followed by a standing TTE, performed within 1-2 minutes of standing. The focused TTE used the apical window to measure velocity time integral across the aortic valve to assess cardiac output. Blood pressure (BP) was measured in the supine and standing positions and patients were asked about symptoms of dizziness and lightheadedness. OH was defined as a change in standing minus supine systolic BP ≤-20 mm Hg or in diastolic BP of ≤-10 mm Hg. Of the 115 enrolled participants, 102 (89%) completed the standing echocardiogram protocol. Among those completing, mean age was 63.4 (SD, 14.8) years (38% were ≥ 70 years), 48% women, and 34% had a BMI ≥ 30 kg/m

conclusionsStanding TTE is safe, well-tolerated, and feasible in the ambulatory setting. Moreover, TTE changes in cardiac output are associated with systolic OH. This clinical assessment shows promise for distinguishing OH etiologies and could inform further research on treatments to prevent OH.

Indexed as

Autonomic dysfunctionBlood pressureOrthostatic hypotensionStandingSupineTransthoracic echocardiogram

Identifiers

PMID40390110
PMCPMC12090504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.