SynthesisJournal of orthopaedic surgery and research2025
Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAppropriate treatment of chondral lesions in the hip greatly improves symptoms and reduces the need for early joint replacement in these patients. Whilst the outcomes of Autologous Chondrocyte Transplantation (ACT) and Autologous Matrix Induced Chondrogenesis (AMIC) in the knee have been thoroughly researched, data on these treatments in the hip is comparatively limited.
aimTo evaluate the outcomes of ACT and AMIC in the hip.
methodsFollowing PRISMA guidelines, a literature search was performed using free text and MeSH terms relating to ACT, AMIC, and variations of these terms across 6 databases. This resulted in 506 abstracts, which were screened down to 12 papers which met the eligibility criteria. Weighted means and pooled estimates using a random effects model were used to assess the success of both procedures.
results628 hips were identified within 12 papers. Weighted mean age 35.8 years (18-55 years), weighted mean lesion size 3.3 cm
conclusionBoth techniques produced significant improvements from baseline. Due to the treatment characteristics, we suggest AMIC is a preferable treatment to ACT. Further research is required to assess the limitations of these procedures concerning chondral lesion size and duration of symptom improvement.
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