Evidence map›Paper›PMID 40389962›Full record

ArticleBMC women's health2025

Does adenomyosis influence tumor characteristics and survival in endometrioid-type endometrial cancer??

Gorkem Ulger, Sevki Goksun Gokulu, Kasim Akay, Hamza Yildiz, Ali Yildizbakan, Tolgay Tuyan Ilhan, Hakan Aytan

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Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gorkem UlgerFaculty of Medicine, Department of Obstetrics and Gynecology, Mersin University, Mersin, Turkey. gorkem.ulger@gmail.com.ORCID http://orcid.org/0000-0002-9565-0078
Sevki Goksun GokuluFaculty of Medicine, Department of Obstetrics and Gynecology, Mersin University, Mersin, Turkey.ORCID http://orcid.org/0000-0002-6581-5716
Kasim AkayDepartment of Obstetrics and Gynecology, Mersin Toros State Hospital, Mersin, Turkey.ORCID http://orcid.org/0000-0002-6098-2259
Hamza YildizFaculty of Medicine, Department of Obstetrics and Gynecology, Mersin University, Mersin, Turkey.ORCID http://orcid.org/0009-0004-6478-813X
Ali YildizbakanDepartment of Obstetrics and Gynecology, Department of Gynecologic Oncology, Osmaniye State Hospital, Osmaniye, Turkey.ORCID http://orcid.org/0000-0002-2343-2645
Tolgay Tuyan IlhanFaculty of Medicine, Department of Obstetrics and Gynecology, Mersin University, Mersin, Turkey.ORCID http://orcid.org/0000-0002-2186-441X
Hakan AytanFaculty of Medicine, Department of Obstetrics and Gynecology, Mersin University, Mersin, Turkey.ORCID http://orcid.org/0000-0002-2553-7715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coexistence of adenomyosis and cancer of the endometrium has attracted heightened scrutiny, leading to inquiries regarding their possible interactions and clinical ramifications. This study sought to assess the influence of adenomyosis on tumor features and survival outcomes in patients with endometrioid-type endometrial carcinoma. MATERIALS AND

methodsA retrospective cohort analysis was performed on 422 patients who underwent surgical intervention for endometrioid-type endometrial carcinoma. The cohort was categorized into two groups according to the presence or absence of adenomyosis. Clinical and pathological data were gathered and evaluated to compare tumor features and survival outcomes between the two cohorts.

resultsAdenomyosis was present in 144 (34.1%) patients. Patients in the adenomyosis group demonstrated significantly higher gravidity and parity compared to those without adenomyosis. Lymphovascular space invasion was detected in 8.3% of the adenomyosis group compared to 17.6% in the non-adenomyosis group (a 53% reduction, p = 0.010). Similarly, rates of myometrial invasion (81.3% vs. 65.5%, p = 0.001), cervical stromal invasion (9.0% vs. 14.1%, p = 0.005), and lymph node metastasis (4.2% vs. 14.4%, p = 0.001) were significantly lower in patients with adenomyosis. The five-year overall survival rate was 90.8% in the adenomyosis group and 87.1% in the non-adenomyosis group, although this difference was not statistically significant (p = 0.689).

conclusionsThis study demonstrates that adenomyosis is associated with a significant reduction in aggressive tumor characteristics such as myometrial invasion, lymphovascular space involvement, and lymph node metastasis in patients with endometrioid-type endometrial cancer. These findings emphasize that adenomyosis may be a potential protective factor in endometrial cancer prognosis and should be considered in clinical risk assessment. Prospective studies with larger cohorts are needed to confirm the long-term effects of adenomyosis on survival.

Indexed as

AdenomyosisCarcinoma, EndometrioidEndometrial NeoplasmsAdultAgedFemaleHumansLymphatic MetastasisMiddle AgedNeoplasm InvasivenessRetrospective StudiesAdenomyosisEndometrial cancerEndometrioid-typeSurvival outcomesTumor characteristics

Identifiers

PMID40389962
PMCPMC12087078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.