Evidence map›Paper›PMID 40389867›Full record

SynthesisBMC medical imaging2025

Detection of carotid artery calcifications using artificial intelligence in dental radiographs: a systematic review and meta-analysis.

Sarah Arzani, Parisa Soltani, Ali Karimi, Maryam Yazdi, Ashraf Ayoub, Zohaib Khurshid, Domenico Galderisi, Hugh Devlin

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah ArzaniChild Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Hezar-Jarib Ave, Isfahan, 81551-39998, Iran. sa.arzan@yahoo.com.
Parisa SoltaniDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
Ali KarimiMaxillogram Maxillofacial Surgery, Implantology and Biomaterial Research Foundation, Istanbul, 8418829912, Turkey. a2022karimi@gmail.com.
Maryam YazdiChild Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Hezar-Jarib Ave, Isfahan, 81551-39998, Iran.
Ashraf AyoubScottish Craniofacial Research Group, School of Medicine, Dentistry and Nursing, Glasgow University MVLS College, Glasgow University Dental School, Glasgow, UK.
Zohaib KhurshidDepartment of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia.
Domenico GalderisiDepartment of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Salerno, Italy.
Hugh DevlinThe Dental School, University of Bristol, Bristol, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarotid artery calcifications are important markers of cardiovascular health, often associated with atherosclerosis and a higher risk of stroke. Recent research shows that dental radiographs can help identify these calcifications, allowing for earlier detection of vascular diseases. Advances in artificial intelligence (AI) have improved the ability to detect carotid calcifications in dental images, making it a useful screening tool. This systematic review and meta-analysis aimed to evaluate how accurately AI methods can identify carotid calcifications in dental radiographs. MATERIALS AND

methodsA systematic search in databases including PubMed, Scopus, Embase, and Web of Science for studies on AI algorithms used to detect carotid calcifications in dental radiographs was conducted. Two independent reviewers collected data on study aims, imaging techniques, and statistical measures such as sensitivity and specificity. A meta-analysis using random effects was performed, and the risk of bias was evaluated with the QUADAS-2 tool.

resultsNine studies were suitable for qualitative analysis, while five provided data for quantitative analysis. These studies assessed AI algorithms using cone beam computed tomography (n = 3) and panoramic radiographs (n = 6). The sensitivity of the included studies ranged from 0.67 to 0.98 and specificity varied between 0.85 and 0.99. The overall effect size, by considering only one AI method in each study, resulted in a sensitivity of 0.92 [95% CI 0.81 to 0.97] and a specificity of 0.96 [95% CI 0.92 to 0.97].

conclusionsThe high sensitivity and specificity indicate that AI methods could be effective screening tools, enhancing the early detection of stroke and related cardiovascular risks. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Artificial IntelligenceCarotid Artery DiseasesRadiography, DentalVascular CalcificationAlgorithmsCarotid ArteriesCone-Beam Computed TomographyHumansRadiography, PanoramicSensitivity and SpecificityArtificial intelligenceAtherosclerotic plaqueCarotid artery thrombosisDental radiographMachine learning

Identifiers

PMID40389867
PMCPMC12090425

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.