Evidence map›Paper›PMID 40389858›Full record

ArticleBMC infectious diseases2025

Emerging antibiotic resistance in bacterial bloodstream infections: a clinical study at the Holy Family Hospital, Nkawkaw, Ghana.

John Gameli Deku, Israel Bedzina, Prince Kwadade Amankwah, Lilian Kekeli Antor, Kenneth Ablordey, Madrid Alhassan, Akatwum Emmanuel Salifu, Robert Awupoli, Arnold Togiwe Luuse, Enoch Aninagyei and 2 more

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

John Gameli DekuDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana. sssdeku@gmail.com.
Israel BedzinaReinbee Medical Laboratory and Wellness Centre, Ho, Ghana.
Prince Kwadade AmankwahDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Lilian Kekeli AntorDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Kenneth AblordeyDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Madrid AlhassanLaboraoty Department, Holy Family Hospital, Nkawkaw, Ghana.
Akatwum Emmanuel SalifuLaboraoty Department, Holy Family Hospital, Nkawkaw, Ghana.
Robert AwupoliLaboraoty Department, Holy Family Hospital, Nkawkaw, Ghana.
Arnold Togiwe LuuseDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Enoch AninagyeiDepartment of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.
Innocent AfekeDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Kwabena Obeng DueduCollege of Life Sciences, Faculty of Health, Education and Life Sciences, Birmingham City University, Birmingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBacteraemia, a critical bloodstream infection caused by various bacterial pathogens, poses significant health challenges, particularly when compounded by antibiotic resistance. This current study determined the prevalence of bloodstream bacterial isolates and their antibiotic-resistant patterns at the Holy Family Hospital, Nkawkaw, Ghana, spanning a six-year period. METHODOLOGY: A hospital-based retrospective study was carried out to review records of bacterial isolates of bloodstream infections and their antibiotic-resistant pattern among patients who visited the Holy Family Hospital between 2018 and 2023. The data was collected into an Excel sheet version 2021, cleaned, and exported to the appropriate statistical software, SPSS v26 for statistical analysis. A P-value less than 0.05 was considered statistically significant for all analyses.

resultsOf 3,228 records in this study, the majority (66.0%) were found to be under 1 year of age, while 18.6% were aged 1-10 years. The prevalence of bacteraemia was 8.7% (95% CI: 7.8-9.7%). Klebsiella species was found to be the most prevalent at 30.2%, followed by S. aureus (26.0%). The highest levels of antibiotic resistance were detected against tetracycline (94.5%), penicillin (92.3%), and chloramphenicol (90.9%). Also, significant resistance was also found against vancomycin (88.3%), cefuroxime (86.5%), and cloxacillin (84.4%). Conversely, amikacin demonstrated the highest susceptibility rate (90.5%), followed by ciprofloxacin (75.0%).

conclusionThe study highlights the significant public health burden posed by bacteraemia and the growing challenge of antibiotic resistance. The prevalence of bacteraemia, particularly caused by Gram-negative organisms such as Klebsiella species and E. coli underscores the need for targeted interventions to improve infection control in healthcare settings.

Indexed as

Anti-Bacterial AgentsBacteremiaBacteriaDrug Resistance, BacterialAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleGhanaHospitalsHumansInfantInfant, NewbornAnti-Bacterial AgentsAntibiotic resistanceBacteriaBloodstream infectionsHoly Family HospitalKlebsiella spp.

Identifiers

PMID40389858
PMCPMC12090518

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.