Evidence map›Paper›PMID 40389852›Full record

ArticleBMC cancer2025

Microwave assisted drug delivery of titanium dioxide/rose Bengal conjugated chitosan nanoparticles for micro-photodynamic skin cancer treatment in vitro and in vivo.

Samir Ali Abd El-Kaream, Nasser Ali Mohamed Hassan, Hassan Saleh Abdullatif Saleh, Mohamed Albahloul Salem Albahloul, Abdalla Mohamed Khedr, Sohier Mahmoud El-Kholey

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Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samir Ali Abd El-KareamApplied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Nasser Ali Mohamed HassanMedical Biophysics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Hassan Saleh Abdullatif SalehChemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
Mohamed Albahloul Salem AlbahloulChemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
Abdalla Mohamed KhedrChemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
Sohier Mahmoud El-KholeyMedical Biophysics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. Dandana.2015@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicro-photodynamic therapy (MWPDT) combines photo-dynamic (PDT) and microwave-dynamic (MWDT) therapies with sensitizers, offers new avenues for cancer treatment. Despite the fact that novel sensitizers for MWPDT have been successfully synthesized, only a few are being employed effectively. The low tumor-targeting specificity, inability to transport sensitizer's deeper intratumorally, and deteriorating tumor microenvironment all restrict their anti-tumor efficacy. The current work was done aiming at microwave assisted drug delivery of titanium dioxide / rose Bengal conjugated chitosan nanoparticles (TiO MATERIALS AND

methodsThe study was conducted in vitro on human SKCA cells (A-375) and the study protocol application groups in vivo on Swiss albino mice treated with 7,12-dimethylbenz[a]anthracene (DMBA)/croton oil only and were not received any treatment for inducing SKCA, and only after SKCA induction the study treatment protocol began, treatment was daily with TiO

resultsRevealed that CSNP can be employed as effective TiO

conclusionThe results indicate that TiO

Indexed as

ChitosanMicrowavesNanoparticlesPhotochemotherapyRose BengalSkin NeoplasmsTitaniumAnimalsApoptosisCell Line, TumorDrug Delivery SystemsHumansMicePhotosensitizing AgentsChitosanPhotosensitizing AgentsRose BengalTitaniumtitanium dioxideChitosan nanoparticleMicro-photodynamicRose BengalSkin cancerTitanium dioxide

Identifiers

PMID40389852
PMCPMC12090424

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