Evidence map›Paper›PMID 40389808›Full record

ArticlePrenatal diagnosis2025

Clinical Outcome and Risk Factors for Progression of Prenatally Diagnosed Fetal Ventriculomegaly: A Retrospective Multicenter Study.

Anouk Moens, Zoe Albersnagel, Marieke B Veenhof, Phebe N Adama van Scheltema, Esther Sikkel, Mariëtte J V Hoffer, Brigitte H W Faas, Dineke Westra, Ilse Feenstra, Emilia K Bijlsma and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Prenatal diagnosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anouk MoensDepartment of Neurology, Leiden University Medical Center, Leiden, the Netherlands.
Zoe AlbersnagelDepartment of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands.
Marieke B VeenhofDepartment of Obstetrics and Gynecology, Division of Fetal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Phebe N Adama van ScheltemaDepartment of Obstetrics and Gynecology, Division of Fetal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Esther SikkelDepartment of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands.
Mariëtte J V HofferDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Brigitte H W FaasDepartment of Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-2311-7725
Dineke WestraDepartment of Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
Ilse FeenstraDepartment of Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
Emilia K BijlsmaDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Gijs W E SantenDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Corrie E ErasmusDepartment of Pediatric Neurology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, the Netherlands.
Cacha M P C D Peeters-ScholteDepartment of Neurology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-3982-6868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the clinical outcome of fetuses with ventriculomegaly (VM), and to identify risk factors for progression of fetal VM in order to improve prenatal counseling. This was a multicenter, retrospective cohort study, comprising 229 cases with VM.

methodsVM was classified as mild, moderate, or severe and isolated or non-isolated. Genetic data were collected. Differences between VM subgroups were described, and risk factors for progression of fetal VM were identified using logistic regression analysis. Outcome was defined as the percentage of live births, termination of pregnancy (TOP) and intra-uterine fetal demise (IUFD).

resultsOf the 229 cases, 109 (47.6%) had mild VM, 60 (26.2%) moderate VM, and 60 (26.2%) severe VM. Progression of VM occurred in 45/153 cases (29.4%), half of which were in the group with severe VM. Dilatation of the 3rd ventricle and neural tube defects were risk factors for progression of VM. The percentage of live births (excluding cases with TOP and unknown outcome) was 93.1% (54/58) in mild VM, 78.6% (22/28) in moderate VM and 92.6% (25/27) in severe VM. In 12/229 cases (5.2%) IUFD occurred. Genetic analysis was performed in 143/229 (62.4%) of cases, showing (likely) pathogenic abnormalities in 41/143 (28.7%) cases, predominantly in mild, non-isolated VM.

conclusionsThis study confirms the clinical relevance of additional genetic investigations in all types of fetal VMs. Further larger prospective research including clinical follow-up is needed to improve prenatal counseling.

Indexed as

HydrocephalusAdultDisease ProgressionFemaleHumansPregnancyPregnancy OutcomePrenatal DiagnosisRetrospective StudiesRisk FactorsUltrasonography, Prenatalexome sequencing‐neurosonographyfetal counselingfetal ventriculomegalyhydrocephalyoutcometermination of pregnancy

Identifiers

PMID40389808
PMCPMC12322251

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