ArticleNano letters2025
The Electric Field in Solid State Nanopores Causes Dissociation of Strong Biomolecular Interactions.
Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- A Nanopore-Gated Subattoliter Silicon Nanocavity for Single-Molecule Trapping and Analysis without Applying an External Force.ACS nano · 2026Article
- Article
- Resonant terahertz-induced stark field disruption of fentanyl's μ-opioid receptor binding for precision overdose reversal.Journal of molecular modeling · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical sensing with nanopores has become a widely used bioanalytical tool. However, it remains unclear if and how the extremely strong electric field generated inside the pores influences biomolecular interactions. Here we show that the field disrupts the strongest known protein-ligand interaction in biology, namely biotin-avidin bonds. Remarkably, the lifetime of the interaction is decreased by at least 4 orders of magnitude. At hundreds of mV, avidin (from egg-white) starts dissociating from biotin-functionalized nanopores over a time scale of minutes even at the maximum bond valency of four. Streptavidin-coated nanoparticles, which form many more bonds, remain bound but exhibit surface mobility due to the field. These results show that nanopore sensors can give very inaccurate results when used for affinity-based detection or biomolecular interaction analysis and that the pore environment should be regarded as potentially invasive for the molecules inside.
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Registered trials
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