Evidence map›Paper›PMID 40389798›Full record

ArticleCognitive, affective & behavioral neuroscience2025

Adolescent cognitive control processing is associated with anxiety in young adulthood during the COVID-19 pandemic.

Grace M Stohr, Anita Harrewijn, Santiago Morales, Selin Zeytinoglu, Zoë E Laky, Parmis Khosravi, Elise M Cardinale, Nicole Lorenzo, Joel Stoddard, Daniel S Pine and 3 more

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Article in Cognitive, affective & behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Grace M StohrEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Anita HarrewijnDepartment of Psychology, Education & Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Santiago MoralesDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Selin ZeytinogluDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.
Zoë E LakyEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Parmis KhosraviEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Elise M CardinaleDepartment of Psychology, The Catholic University of America, Washington, DC, USA.
Nicole LorenzoPsychology Department, American University, Washington, DC, USA.
Joel StoddardPediatric Mental Health Institute, Children'S Hospital Colorado, Department of Psychiatry & Neuroscience Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Daniel S PineEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Nathan A FoxDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.
Melissa A BrotmanEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Simone P HallerEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. simone.haller@nih.gov.

Funding

Trajectories of Behavioral Inibition and Risk for AnxietyU01MH093349 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2011 to 2020
$6.6M
fMRI Study Of Risk Of Mood/Anxiety Disorders In ChildrenZ01MH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.7M
Intramural NIH HHS Z01 MH002782NIMH Intramural Program ZIA-MH002782NIMH NIH HHS U01 MH093349NIMH NIH HHS U01MH093349
6 · The paper itself

Abstract

The COVID-19 pandemic has been associated with widespread increases in levels of stress and anxiety among young adults. Given that responses to stressful life events vary, it is important to understand how pre-pandemic neurocognitive factors shape reactivity to stress and susceptibility to anxiety. The present study examines associations between pre-pandemic brain activation patterns during cognitive control processing and anxiety trajectories during the pandemic. Participants were recruited as part of an ongoing longitudinal study of temperament and socioemotional development (N = 291). Forty-seven participants completed a cognitive control fMRI task and anxiety measures in late adolescence before the pandemic. In young adulthood, anxiety was assessed three times during the COVID-19 pandemic. Multivariate whole-brain models tested whether activation patterns during the conflict and error processing associated with latent anxiety indices derived from a latent growth curve model. Neural response during conflict and error processing related to anxiety in distinct cortical and subcortical regions. Level of anterior cingulate cortex engagement during cognitive control related to anxiety. However, during error processing, level of engagement in the dorsolateral prefrontal, rather than anterior cingulate cortex, related to anxiety. This work provides preliminary evidence for the predictive utility of prestress neurocognitive factors for young adults' anxiety response during a uniquely stressful event. Adolescence is a critical time for early identification of youth at risk to create targeted interventions to enhance stress resilience.

Indexed as

AnxietyBrainCOVID-19Executive FunctionAdolescentBrain MappingFemaleGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingMaleYoung AdultAdolescentsAnxietyCognitive controlCOVID-19 pandemicFMRIStress

Identifiers

PMID40389798
PMCPMC12464013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.