Evidence map›Paper›PMID 40389726›Full record

ArticleScientific reports2025

Deciphering the role of histone modifications in memory and exhausted CD8 T cells.

Hua Huang, Amy E Baxter, Zhen Zhang, Charly R Good, Katherine A Alexander, Zeyu Chen, Paula A Agudelo Garcia, Parisa Samareh, Sierra M Collins, Karl M Glastad and 7 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Epigenetic regulation of CD8Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hua Huang *Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Amy E Baxter *Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Zhen Zhang *Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Charly R Good *Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Katherine A Alexander *Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Zeyu ChenDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Paula A Agudelo GarciaEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Parisa SamarehEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Sierra M CollinsEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Karl M GlastadEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Lu WangEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Gregory DonahueEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Sasikanth ManneDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Josephine R GilesDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Junwei ShiEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Shelley L BergerEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. bergers@pennmedicine.upenn.edu.
E John WherryDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. wherry@pennmedicine.upenn.edu.

Funding

Synergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI E. John Wherry · 2015 to 2026
$30.8M
Role of PCAF/GCN5 Acetylation on p53 TransactivationR01CA078831 · NCI · WISTAR INSTITUTE · PI BERGER, SHELLEY L · 1999 to 2022
$7.8M
Interaction between nuclear epigenetic and metabolic pathways in cancerR35CA263922 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 2022 to 2026
$4.8M
Mechanisms of gene regulation in cancerR50CA305050 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Charly Ryan Good · 2025 to 2026
$460k
Novel Roles of p53 Post Translational Modifications in CancerF32CA232466 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GOOD, CHARLY RYAN · 2019 to 2019
$53k
NCI NIH HHS F32 CA232466NCI NIH HHS R01 CA078831NCI NIH HHS R35 CA263922NCI NIH HHS R50 CA305050NIAID NIH HHS P01 AI108545NIH HHS CA078831NIH HHS CA232466
6 · The paper itself

Abstract

Exhausted CD8 T cells (T

Indexed as

CD8-Positive T-LymphocytesHistone CodeHistonesImmunologic MemoryMemory T CellsAnimalsChromatinEpigenesis, GeneticGene Expression RegulationHumansMicePromoter Regions, GeneticProtein Processing, Post-TranslationalChromatinHistones

Identifiers

PMID40389726
PMCPMC12089470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.