Evidence map›Paper›PMID 40389716›Full record

ArticleThe Journal of antibiotics2025

Isolation and synthesis of a new cyclic tetrapeptide from marine-associated Bacillus sp. and its bacterial biofilm formation inhibitory activity.

Shuaiqi Ma, Shixin Li, Li Song, Asma Riaz, Ruifeng Huang, Shaofen Zhou, Jingnan Qiu, Zonglin Chu, Jian He

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuaiqi MaGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Shixin LiGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Li SongGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Asma RiazGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Ruifeng HuangGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Shaofen ZhouGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Jingnan QiuGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Zonglin ChuGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Jian HeGroup of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. jianhe@smu.edu.cn.

Funding

Guangdong Science and Technology Department (Science and Technology Department, Guangdong Province) 2022A1515010182Guangdong Science and Technology Department (Science and Technology Department, Guangdong Province) 2023A1515012933National Natural Science Foundation of China (National Science Foundation of China) 81773556Southern Medical University (SMU) B1040903
6 · The paper itself

Abstract

A new cyclic tetrapeptide named Cereusitin B (1), along with a number of known cyclic dipeptides was isolated from the fermentation broth of a marine-associated Bacillus sp. I-2. The structure of Cereusitin B, cyclo-(L-phenylalanyl-trans-4-hydroxy-L-prolyl-L-leucyl-L-alanine), was determined through extensive analysis using high-resolution electrospray ionization mass spectrometry and NMR spectral data (1D, 2D NMR), and its identity was further confirmed by Marfey' method and chemical synthesis. The antimicrobial activity tests showed that compound 2 was moderately active against Candida albicans with a MIC value of 125 µg mL

Indexed as

Anti-Bacterial AgentsBacillusBiofilmsPeptides, CyclicCandida albicansFermentationMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsSpectrometry, Mass, Electrospray IonizationStaphylococcus aureusAnti-Bacterial AgentsPeptides, Cyclic

Identifiers

PMID40389716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.