Evidence map›Paper›PMID 40389678›Full record

ArticleNature metabolism2025

Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of

Anastasia Tsyben, Andreas Dannhorn, Gregory Hamm, Manthos Pitoulias, Dominique-Laurent Couturier, Ashley Sawle, Mayen Briggs, Alan J Wright, Cara Brodie, Lee Mendil and 17 more

Abstract read
In one paragraph

Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Anastasia TsybenCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Andreas DannhornIntegrated BioAnalysis, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca, Cambridge, UK.ORCID http://orcid.org/0000-0002-1087-4057
Gregory HammIntegrated BioAnalysis, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca, Cambridge, UK.
Manthos PitouliasCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9814-0604
Dominique-Laurent CouturierCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Ashley SawleCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2985-5059
Mayen BriggsCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Alan J WrightCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4577-5681
Cara BrodieCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Lee MendilCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Jodi L MillerCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6870-204X
Eleanor C WilliamsAstraZeneca, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-8023-9550
Lovisa FranzénSafety Sciences, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca, Gothenburg, Sweden.
Grand De JongWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Tannia GraciaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Fani MemiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Omer Ali BayraktarWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID http://orcid.org/0000-0001-6055-277X
Ram AdapaCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Jyotsna RaoCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Ariadna González-FernándezNational Physical Laboratory, Teddington, UK.ORCID http://orcid.org/0009-0003-3225-4718
CRUK Rosetta Grand Challenge Consortium
Josephine BunchNational Physical Laboratory, Teddington, UK.
Zoltan TakatsDepartment of Metabolism, Digestion and Reproduction, Imperial College, London, UK.ORCID http://orcid.org/0000-0002-0795-3467
Simon T BarryAstraZeneca, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-8511-0588
Richard J A GoodwinIntegrated BioAnalysis, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca, Cambridge, UK.ORCID http://orcid.org/0000-0001-5699-8488
Richard MairCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. Richard.Mair@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0001-8235-5689
Kevin M BrindleCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. kmb1001@cam.ac.uk.ORCID http://orcid.org/0000-0003-3883-6287

Funding

Cancer Research UK (CRUK) C197/A17242Cancer Research UK (CRUK) C197/A25045Cancer Research UK (CRUK) C197/A29580Cancer Research UK (CRUK) C9685/A25177Wellcome Trust
6 · The paper itself

Abstract

Transcriptomic studies have attempted to classify glioblastoma (GB) into subtypes that predict survival and have different therapeutic vulnerabilities

Indexed as

Brain NeoplasmsGlioblastomaGlucoseMass SpectrometryAnimalsCarbon IsotopesGlycolysisHumansMicePhenotypeTumor MicroenvironmentCarbon-13Carbon IsotopesGlucose

Identifiers

PMID40389678
PMCPMC12116388

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.