Evidence map›Paper›PMID 40389608›Full record

ArticleNature methods2025

A palette of bridged bicycle-strengthened fluorophores.

Junwei Zhang, Kecheng Zhang, Kui Wang, Bo Wang, Siyan Zhu, Hongping Qian, Yumiao Ma, Mengling Zhang, Tianyan Liu, Peng Chen and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Year in review 2025.Nature methods · 2026
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Junwei ZhangCollege of Future Technology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, State Key Laboratory of Membrane Biology, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-3857-3205
Kecheng ZhangCollege of Future Technology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, State Key Laboratory of Membrane Biology, Peking University, Beijing, China.
Kui WangInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-9436-3632
Bo WangPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0009-0004-0989-2225
Siyan ZhuPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Hongping QianCollege of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, China.
Yumiao MaBSJ Institute, Beijing, China.
Mengling ZhangCollege of Future Technology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, State Key Laboratory of Membrane Biology, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-6107-9715
Tianyan LiuCollege of Future Technology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, State Key Laboratory of Membrane Biology, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-1982-2736
Peng ChenPKU-Nanjing Institute of Translational Medicine, Nanjing, China.
Yuan ShenPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0009-0003-3693-4016
Yunzhe FuDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Shilin FangInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Xinxin ZhangInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Peng ZouPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-9798-5242
Wulan DengPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-7450-7128
Yu MuInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-9297-4854
Zhixing ChenCollege of Future Technology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, State Key Laboratory of Membrane Biology, Peking University, Beijing, China. zhixingchen@pku.edu.cn.ORCID http://orcid.org/0000-0001-5962-7359

Funding

Beijing Municipal Science and Technology Commission Z221100003422013Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2020YFA0509502Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 202YFF0502904National Natural Science Foundation of China (National Science Foundation of China) 32170566
6 · The paper itself

Abstract

Organic fluorophores are the keystone of advanced biological imaging. The vast chemical space of fluorophores has been extensively explored in search of molecules with ideal properties. However, within the current molecular constraints, there appears to be a trade-off between high brightness, robust photostability, and tunable biochemical properties. Herein we report a general strategy to systematically boost the performance of donor-acceptor-type fluorophores, such as rhodamines, by leveraging SO

Indexed as

Bridged Bicyclo CompoundsFluorescent DyesAnimalsHumansRhodaminesSingle Molecule ImagingZebrafishBridged Bicyclo CompoundsFluorescent DyesRhodamines

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.