Evidence map›Paper›PMID 40389590›Full record

ArticleScientific reports2025

No independent association between dietary calcium/vitamin D and appendicular lean mass index in middle-aged women: NHANES cross-sectional analysis (2011-2018).

Zhengwei Lai, Fang Jin, Chunmei Zhu, Zhongxin Zhu

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhengwei LaiDepartment of Gynaecology, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 311200, Zhejiang, China.
Fang JinDepartment of Osteoporosis Care and Control, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 311200, Zhejiang, China.
Chunmei ZhuCommunity Health Service Center of Puyang, Hangzhou, 311200, Zhejiang, China.
Zhongxin ZhuDepartment of Osteoporosis Care and Control, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 311200, Zhejiang, China. orthozzx@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle preservation during midlife is critical for preventing sarcopenia in aging populations. While calcium and vitamin D are recognized for their musculoskeletal benefits, their specific associations with muscle mass in middle-aged women remain unclear. This cross-sectional study analyzed data from 2,496 women aged 40-59 years in the NHANES (2011-2018). Multivariable linear regression models adjusted for demographics, lifestyle factors, and comorbidities evaluated associations between dietary calcium, vitamin D intakes and appendicular lean mass index (ALMI), with subgroup analyses by menopausal status and other covariates. After full adjustment, neither dietary calcium nor vitamin D intake showed significant associations with ALMI. Null findings persisted across all subgroups. Dietary calcium and vitamin D intake were not independently associated with ALMI in middle-aged women. These results highlight the need to investigate broader nutritional patterns or synergistic mechanisms influencing muscle health during midlife.

Indexed as

Calcium, DietaryMuscle, SkeletalVitamin DAdultBody CompositionBody Mass IndexCross-Sectional StudiesFemaleHumansMiddle AgedNutrition SurveysSarcopeniaCalcium, DietaryVitamin DAppendicular lean massCalciumMidlife womenNHANESVitamin D

Identifiers

PMID40389590
PMCPMC12089267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.