Evidence map›Paper›PMID 40389580›Full record

ArticleScientific reports2025

Healthy lifestyle, daytime sleepiness, and gut microbiome composition are determinants of functional strength in humans: a cross-sectional study.

Friederike Norkeweit, Kristina Schlicht, Nathalie Rohmann, Katharina Hartmann, Kathrin Türk, Ute Settgast, Dominik M Schulte, Felix Gilbert, Tobias Demetrowitsch, Fynn Brix and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Friederike NorkeweitInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.
Kristina SchlichtInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.
Nathalie RohmannInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.
Katharina HartmannInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.
Kathrin TürkInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.
Ute SettgastDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany.
Dominik M SchulteInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.
Felix GilbertInstitute of Clinical Molecular Biology (IKMB), Kiel University, 24118, Kiel, Germany.
Tobias DemetrowitschDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, 24105, Kiel, Germany.
Fynn BrixDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, 24105, Kiel, Germany.
Corinna BangInstitute of Clinical Molecular Biology (IKMB), Kiel University, 24118, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology (IKMB), Kiel University, 24118, Kiel, Germany.
Karin SchwarzDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, 24105, Kiel, Germany.
Matthias LaudesInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.
Corinna GeislerInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany. corinna.geisler@uksh.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age, metabolic inflammation, sleep patterns, lifestyle choices, and gut microbiome composition were investigated as factors influencing functional strength. The Northern German FoCus cohort subgroup (394 women, 233 men) was categorized into six groups based on weekly sports activity and handgrip strength (HGS) measurements. The analyses included anthropometric data, clinical biochemistry, medication, sleep duration, healthy lifestyle score (HLS), 16 S rRNA gut microbiota, serum and urine metabolomics, bile acids, and an adapted dietary inflammatory index (ADII) score. Associations were found between age, inflammation, and low functional strength, with sleep duration increasing the odds and a healthy lifestyle decreasing the risk. Urine metabolomics revealed differences in enrichment analyses. No significant differences were observed in the Chao1 and InVSimpson indices between the groups. At the genus level, some species were associated with daily sports activity, whereas others were associated with HGS measurements. Clostridium XIVa was found only in high- and medium-HGS groups, while Alistipes, Odoribacter, and Streptococcus decreased with activity. Thus, tailored lifestyle interventions may reduce the risk of poor functional strength.

Indexed as

Gastrointestinal MicrobiomeHand StrengthHealthy LifestyleAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedSleepActivityCohort studyGut microbiota diversityMetabolomicsMicrobiota interactionsStrength

Identifiers

PMID40389580
PMCPMC12089321

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.