ArticleScientific reports2025
Obesity-induced adipocytes promote diabetes mellitus by regulating β islet cell function through exosome miR-138-5p.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Pancreatic-liver crosstalk, novel molecular mediators, and 2025 therapeutic breakthroughs.World journal of methodology · 2026Review
- Extracellular Vesicle-Mediated Local and Systemic Communication in Metabolic Diseases.International journal of molecular sciences · 2026Review
- miRNAs as cell-intrinsic epigenetic regulators in muscle in type 2 diabetes.Signal transduction and targeted therapy · 2026Article
- MicroRNA-Driven Regulation of β-Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives.Acta physiologica (Oxford, England) · 2026Review
- From oversight to insight: the curious case of the endothelial insulin receptor.Blood vessels, thrombosis & hemostasis · 2026Review
- Pathophysiological Roles of Obesity-Induced Alterations in Extracellular Vesicles Derived from Adipose Tissue and Adipocytes.Current obesity reports · 2026Review
- RNA-based approaches in the diagnosis and treatment of obesity.Frontiers in pharmacology · 2026Review
- Exosomal non-coding RNAs in autoimmune diseases: molecular mechanisms and potential applications.Frontiers in immunology · 2026Review
- Exploring the Evidence for Personalized Pharmacotherapy in Type 2 Diabetes-A Systematic Review.Journal of personalized medicine · 2025Review
- The Inflammatory Bridge Between Type 2 Diabetes and Neurodegeneration: A Molecular Perspective.International journal of molecular sciences · 2025Review
- The therapeutic effect of exosomes in type 2 diabetes mellitus and its complications.Frontiers in medicine · 2025Review
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Authors and funding
2 authors.
Funding
Abstract
Insulin dysfunction can lead to type 1 diabetes mellitus (T1DM), inducing an increase in blood glucose levels. Unfortunately, there remains a need for more effective clinical treatments for DM. Obesity is closely associated with islet dysfunction, but these inside mechanisms remain unclear. We indicated that obesity-induced adipocytes inhibit insulin secretion (IS) from β islet cells (β-cells) by elevating the expression of their exosome miR-138-5p. Our study proved the high expression of miR-138-5p in exosomes isolated from the fat tissue of obese mice, as well as in exosomes derived from obesity-induced 3T3-L1 cells. The underlying mechanism possibly involves the upregulation of miR-138-5p which suppressed IS while increasing apoptosis in MIN6 cells. miR-138-5p knockdown upregulated insulin production and decreased apoptosis in MIN6 cells. Moreover, dual-luciferase reporter assays revealed the direct regulating effects of miR-138-5p on SOX4. Moreover, SOX4 expression affects the abundance of proteins involved in the Wnt/β-catenin pathway. Under obesity conditions, miR-138-5p in adipocyte exosomes affects IS and ultimately β-cell function by regulating the SOX4-mediated Wnt/β-catenin pathway in β cells. These results not only presented new insights into the interaction between obesity and T1DM but also provide new possible therapeutic mechanisms for obesity-related T1DM.
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