ArticleScientific reports2025
The potential effect of gut microbiota on the secretion of selected cytokines by human cells in vitro.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gut Microbiota Modulation in Asthma-An In Vitro Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Colonization of the gut early in life plays a significant role in guiding the development of the immune system. The effect of individual intestinal bacterial strains on the asthma development is the subject of numerous scientific studies. The aim of the study was to determine the role and the potential mechanism of action of intestinal microflora on secretion of cytokines and potential predisposition to asthma development. The effect of Parabacteroides distasonis (PD), Bacteroides vulgatus (BV) Clostridium perfringens (CP) and Ruminococcus albus (RA) lysates on the secretion of IL-4, IL-5, IL-8 (CXCL8) and IL-13 in human peripheral blood mononuclear cells, monocytes and HT-29 cells has been analyzed by enzyme-linked immunosorbent assays. RA and PD 400 µg lysates significantly increased secretion of IL-5 by PBMC compared to control (p < 0.05). In addition, BV, CP, PD and RA 100 µg lysates significantly increased IL-8 secretion by PBMC, as well as BV, PD and RA 100 µg lysates by monocytes compared to control (p < 0.05). Moreover, PD 100 µg and 400 µg lysates significantly increased secretion of IL-8 by HT-29 cells compared to BV 100 µg and 400 µg lysates (p < 0.05). CP, BV, PD and RA 100 µg lysates significantly lowered IL-13 secretion by PBMC vs. control (p < 0.001). For a better understanding of the mechanisms of action of gut microflora and their impact on parameters important in asthma, complex studies which compare the asthma and control samples should be carried out in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.