Evidence map›Paper›PMID 40389459›Full record

ArticleScientific reports2025

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions.

Neha Gupta, Salah A Baker, Kenton M Sanders, Kaneez E Rabab, Denzel Kf Thean, Tuleen Alkawadri, Caoimhin S Griffin, Gerard P Sergeant, Mark A Hollywood, Keith D Thornbury and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Orai storeoperated CaChannels (Austin, Tex.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Neha GuptaSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Salah A BakerDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Kenton M SandersDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Kaneez E RababSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Denzel Kf TheanSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Tuleen AlkawadriSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Caoimhin S GriffinSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Gerard P SergeantSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Mark A HollywoodSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Keith D ThornburySmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland.
Bernard T DrummSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland. bernard.drumm@dkit.ie.

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Yumei Feng Earley · 2019 to 2026
$20.3M
Pacemaker cells and mechanism in the renal pelvisR01DK124509 · NIDDK · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2020 to 2023
$1.9M
Government of Ireland - European Union Regional Development Framework - TU RISE CREATE-DkIT Scholarship CREATE-PhD-4Irish Higher Education Authority Technological University Transformation Fund TUTFY2144NIDDK NIH HHS R01 DK124509NIGMS NIH HHS P20 GM130459NIH HHS R01 DK124509
6 · The paper itself

Abstract

Anoctamin-1 Ca

Indexed as

Anoctamin-1Muscle ContractionMuscle, SmoothUrethraAnimalsCalcium SignalingFemaleInterstitial Cells of CajalMaleMiceMice, Inbred C57BLMyocytes, Smooth MuscleANO1 protein, mouseAnoctamin-1Ani9ANO1Ca2+-activated-Cl−IncontinenceSmooth muscleUrethra

Identifiers

PMID40389459
PMCPMC12089485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.